Size cut-offs established for rectal neuroendocrine neoplasm recurrence

A recent retrospective study involving 1,011 patients identified critical size thresholds for rectal neuroendocrine neoplasms (NENs). For grade 1 tumors, a 0.7 cm cut-off showed 100% sensitivity and 79% specificity, indicating minimal recurrence risk. Conversely, grade 1 tumors with lymphovascular invasion necessitated a 1.5 cm cut-off. Grade 2 NENs, which exhibited a 22.9% lymph node metastasis rate, require continual surveillance regardless of size. These insights aim to refine follow-up strategies for improved patient management.