Emerging research highlights the significant impact of circadian rhythm on gastrointestinal cancer (GIC) progression and treatment. Modulating key circadian genes, like bmal1 and per1, shows potential in suppressing tumor advancement through various pathways. The review emphasizes the crucial role these genes play in GIC initiation, metastasis, metabolism, and therapeutic resistance. Current and future therapeutic strategies incorporating circadian rhythm modulation could enhance the effectiveness of treatments, particularly for patients diagnosed at advanced stages of the disease.
Review by Han J, Xiong Z (…) Cai M et 10 al. in Ann Med