A tailored antimicrobial stewardship program (AMS) in pancreatic surgery cut overall surgical site infections from 30.1% to 20.6% and organ-space infections from 26.3% to 19.3%. It also boosted prophylaxis coverage for rectal screening (87.2% to 100%) and biliary isolates (59.7% to 68.7%). The intervention improved clinical outcomes, reduced antibiotic use and length of stay, and saved €247,460. These results suggest that AMS strategies focused on local resistance patterns can meaningfully improve care and reduce costs in high-risk surgical populations.
Multicenter Study by De Pastena M, Paiella S (…) Salvia R et 27 al. in JAMA Netw Open