Combining dexmedetomidine with hyperbaric bupivacaine significantly delayed postoperative pain onset for patients undergoing appendectomy under spinal anesthesia, achieving mean times of 259.43 and 454.65 minutes for the two dexmedetomidine groups, compared to 154.04 minutes in the control group. The study maintained overall hemodynamic stability, although group 3 experienced lower heart rates and blood pressure, with some reports of nausea. No respiratory depression occurred, highlighting dexmedetomidine’s safety in enhancing analgesia.
Randomized Controlled Trial by Thakur SK, Khan SA (…) Parajuli SB et 3 al. in Medicine (Baltimore)
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