Post-surgical analysis reveals men experience significantly worse recurrence-free survival after liver resection for HCC and ICC compared to women, with 5-year rates of 30.0% versus 43.9% and 18.7% versus 26.8%, respectively. Male murine models also showed larger tumor recurrences linked to increased immunosuppressive cells. The male-specific SRY gene promotes an immunosuppressive microenvironment, implicating potential targeted therapies for improving outcomes in men suffering from liver malignancies.
Journal Article by Zhang W, Chen LF (…) Zhang XF et 14 al. in Int J Surg
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