Early VTE Prophylaxis Cuts Risk of Complications in Major Trauma Patients

Initiating pharmacologic venous thromboembolism (VTE) prophylaxis within 24 hours of major trauma admission dramatically lowers VTE risk by 42%, according to a large cohort study. Among 6,569 patients, those receiving early treatment experienced significantly fewer VTE events (2.8% compared to 7.8%) and showed reduced mortality rates (0.6% vs. 1.8%). Crucially, early initiation did not increase the risk of bleeding complications, supporting a shift towards this practice as standard care.