Key Factors in Reducing Anastomotic Leakage Risk in Gastrointestinal Surgery

Anastomotic leakage (AL) poses a significant threat to recovery in gastrointestinal surgeries. Key risk factors include ASA scores of 3-4, male gender, diabetes, hypertension, and chronic kidney disease. Preoperative mechanical bowel preparation with oral antibiotics can markedly decrease AL incidence. Additionally, intraoperative techniques—like collagen sealants and indocyanine green imaging—effectively mitigate risks. However, NSAID use correlates with increased AL rates. Future studies should focus on multicenter trials for improved prevention strategies.