New margin classifications reshape treatment strategies for hilar cholangiocarcinoma

A retrospective analysis of 218 patients reveals that refined resection margin classifications significantly impact recurrence patterns in hilar cholangiocarcinoma. Adjuvant radiotherapy sharply reduces local recurrence rates, particularly in patients with narrow-clear and invasive margins. Notably, no recurrences were observed in patients with wide-clear, narrow-clear, or dysplastic margins after radiotherapy. Tailoring postoperative strategies based on margin status may enhance outcomes and address the critical challenges of recurrence risk.