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New margin classifications reshape treatment strategies for hilar cholangiocarcinoma

A retrospective analysis of 218 patients reveals that refined resection margin classifications significantly impact recurrence patterns in hilar cholangiocarcinoma. Adjuvant radiotherapy sharply reduces local recurrence rates, particularly in patients with narrow-clear and invasive margins. Notably, no recurrences were observed in patients with wide-clear, narrow-clear, or dysplastic margins after radiotherapy. Tailoring postoperative strategies based on margin status may enhance outcomes and address the critical challenges of recurrence risk.

Journal Article by Park SH, Kim NR (…) Choi GH et 4 al. in Ann Surg Oncol

© 2025. Society of Surgical Oncology.

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