Nutritional and inflammatory markers can significantly influence outcomes after esophagectomy for esophageal squamous cell carcinoma.

• Malnutrition and systemic inflammation adversely affect recovery and surgical results.
• Key markers include albumin, C-reactive protein, and the neutrophil-to-lymphocyte ratio, which guide patient risk assessments.

Utilizing these markers can enhance preoperative planning and postoperative monitoring.

• Future approaches may incorporate novel biomarkers and AI for tailored interventions.