Gastrointestinal cancers present sharp disparities in working-age populations across BRICS-plus countries.

In 2021, China reported over 17 million disability-adjusted life years (DALYs) for gastrointestinal cancers, leading among BRICS-plus nations.

• Colorectal, esophageal, stomach, and liver cancers make up over 70% of the burden, with significant reductions noted for esophageal and stomach cancers in most countries.
• Men generally face a higher incidence, except for gallbladder cancers, which disproportionately affect women.

Targeting prevention strategies is crucial, especially for individuals aged 60-64, the most affected demographic.