Early use of NSAIDs post-proctectomy increases the risk of early anastomotic leaks.

• 8.7% overall rate of anastomotic leaks, with early NSAID use linked to higher rates (7.7% vs. 4.7%, p = 0.030).
• Non-selective NSAIDs and multiple doses significantly heighten early leak risk (OR 1.717, p = 0.012; OR 1.687, p = 0.016).

Consider timing and drug selection when prescribing NSAIDs to minimize complications.

• Increased perioperative bleeding noted with NSAID use (4.0% vs. 1.2%, p = 0.003).
• Male patients and those without diverting stomas are at greater risk for early leaks related to NSAIDs.