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Piperacillin-tazobactam outperforms cefoxitin for pancreatoduodenectomy

Switching to piperacillin-tazobactam for prophylaxis significantly lowers surgical site infections and pancreatic fistula rates in open pancreatoduodenectomy.

  • Patients on piperacillin-tazobactam had 30% fewer surgical site infections and pancreatic fistulas compared to those on cefoxitin.
  • The switch is backed by data from over 4,000 patients, with a clear trend toward piperacillin-tazobactam usage increasing.

Consider adopting piperacillin-tazobactam to enhance perioperative outcomes for your patients.

Journal Article by Tsilimigras DI, Woldesenbet S (…) Pawlik TM et 5 al. in HPB (Oxford)

Copyright © 2025 International Hepato-Pancreato-Biliary Association Inc. Published by Elsevier Ltd. All rights reserved.

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