Robotic intracorporeal single-stapled anastomosis (RISS) cuts anastomotic leakage rates after minimally invasive total mesorectal excision (TME) for rectal cancer.

• RISS showed a 90-day leakage rate of 5.6% vs. 16.7% for double-stapled technique (DST).
• RISS also reduced reintervention rates (1.4% vs. 10.4%) and overall morbidity (33.3% vs. 52.5%).

This method not only enhances surgical outcomes but may also lower the costs associated with complications.

• Each additional stapler firing increased leakage risk (OR 1.62), with ≥3 firings predicting high risk (OR 4.92).