Applying human-derived fibrin sealant after gastric endoscopic submucosal dissection (ESD) significantly enhances patient outcomes.

• Delayed hemorrhage rates dropped to 1.7% in the fibrin group versus 6.9% in controls (p < 0.001).
• One month post-ESD, the fibrin group saw a wound healing rate of 65.4%, compared to 51.1% for controls (p = 0.014).

This sealant not only reduces bleeding but also minimizes postoperative pain and accelerates healing.

• Risk factors for bleeding include lesion location in the lower stomach and larger specimen sizes (≥60 mm).