Exercise significantly improves health-related quality of life (HRQoL) and mental health in colorectal cancer survivors.

• Overall, exercise showed a notable increase in HRQoL (0.48) and reduced fatigue (-0.44), depression (-0.29), and anxiety (-0.29).
• Supervised moderate-intensity exercise (3-5.9 METs), 30-60 minutes, 3-4 times weekly, maximizes benefits.

Incorporating structured exercise into post-treatment plans can enhance recovery and overall patient well-being.

• Resistance training ranked highest for improving HRQoL (91.8%), while combined aerobic and resistance training was most effective for reducing symptoms (81.7%-82.4%).