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Drain CRP Level on Postoperative Day 4 Predicts Pancreatic Fistulas

Drainage fluid C-reactive protein levels can help predict clinically relevant pancreatic fistulas post-pancreaticoduodenectomy.

  • 15.1% of patients developed clinically relevant pancreatic fistulas.
  • CRP levels in drainage fluid on postoperative day 4 ≥6.5 mg/dl have an odds ratio of 4.95 for predicting fistulas, with a negative predictive value of 95.6%.

Consider using drain CRP measurements to enhance decision-making for patient management after surgery.

  • Serum and drain CRP levels showed strong correlation, indicating that both can be valuable for postoperative assessments.

Journal Article by Baba K, Uemura K (…) Takahashi S et 8 al. in Ann Surg Oncol

© 2026. The Author(s).

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