HPB & Spleen · 26 February 2026

Circulating Tumor DNA Predicts Recurrence in Pancreatic Cancer

Preoperative and postoperative circulating tumor DNA (ctDNA) are crucial for predicting outcomes in pancreatic cancer patients undergoing surgery.

Preoperative ctDNA presence linked to 2.08-fold higher risk of disease-free survival (DFS) and 2.31-fold increased risk of overall survival (OS).
Postoperative positivity raises the risk of DFS by 3.29 times and OS by 3.42 times.

Monitoring ctDNA can refine patient selection for neoadjuvant, surgical, and adjuvant therapies, enhancing personalized treatment strategies.

Journal Article by Borges FC, Pinto MS (…) Büchler MW et 11 al. in Ann Surg

read the whole article in Ann Surg

open it in PubMed

Summaries are written to help you decide what to read. They do not replace the full paper.

Free · 5 minutes a day

Get every new paper in HPB & Spleen.

Plus the Daily Selection: the five most relevant papers of the day, each cut to its key points.

The latest stitches

Ann Surg Oncol3 Nov 2026

Nutrition and immune blood markers predict survival in gallbladder cancer

Patients with better blood nutrition scores lived longer after surgery for gallbladder cancer, in a study of 1,312 patients.

HPB & Spleen3 Nov 2026

Liver cancer drugs around surgery remain unproven

Drugs given around liver cancer surgery have mostly failed, but one recent trial showed a real benefit.

Ann Surg Oncol2 Nov 2026

Pancreatic ductoscopy guides tissue preservation

In two older patients having robotic surgery for a pancreatic growth, ductoscopy and checks of the cut edge let surgeons leave the remaining pancreas in place.

All papers in HPB & Spleen →