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Immediate Endoscopic Necrosectomy Cuts Recovery Time in Pancreatitis

Immediate endoscopic necrosectomy (den) after drainage significantly speeds recovery in patients with necrotizing pancreatitis.

  • Time to clinical success was 29 days with immediate den, compared to 44 days with the step-up approach (p = .009).
  • Adverse events were similar between groups: 24% for immediate den vs. 22% for step-up (p = .79).

Consider immediate den for faster patient recovery without increased risk.

  • Technical success rates were high and comparable: 100% for immediate den vs. 97% for step-up (p > .99).

Journal Article by Saito T, Fujisawa T (…) Nakai Y et 46 al. in Gastroenterology

Copyright © 2026 AGA Institute. Published by Elsevier Inc. All rights reserved.

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