New study evaluates indocyanine green fluorescence to prevent chyle leakage during esophagectomy, but results are mixed.

• Chyle leakage incidence: 17% in the ICG group vs. 10% in controls (p = 0.163).
• ICG influenced intraoperative decisions in 36% of cases, with successful thoracic duct visualization in 85%.

Surgeons may not see a reduction in chyle leakage, but ICG can aid in intraoperative management decisions.

• Conservative treatment was used for all ICG group leakage cases vs. two re-interventions in the control group (p = 0.271).