Surgical resection significantly increases cure probabilities for pancreatic ductal adenocarcinoma.

• Cure probability for patients undergoing resection is 25.24%, compared to 6.82% for those who do not.
• Neoadjuvant chemotherapy before surgery improves cure rates (30.0% vs 17.05% with upfront surgery).

Earlier detection and combined treatment strategies are crucial for improving long-term outcomes.

• Cure probabilities decrease with older age and advanced clinical stage, underscoring the need for timely intervention.