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Appendix, Gallbladder and Surgical Emergencies ·

Whole Blood Prehospital Transfusion Doesn’t Lower Mortality

Using whole blood for prehospital transfusions in trauma patients does not significantly decrease 30-day mortality compared to blood components.

  • 30-day mortality was 25.9% for whole blood vs. 20.5% for components (adjusted odds ratio 1.24, p=0.24).
  • No significant differences in adverse events between groups were noted.

Surgeons should consider these findings when deciding on prehospital transfusion strategies for hemorrhagic shock patients.

  • Storage age of whole blood (1-14 days vs. 15-21 days) did not impact 30-day mortality significantly.

Journal Article by Sperry JL, Guyette FX (…) Wisniewski SR et 28 al. in N Engl J Med

Copyright © 2026 Massachusetts Medical Society.

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