Metabolic and Bariatric Surgery · 16 June 2026

EndoBarrier Shows Promise for Type 2 Diabetes in Obesity

Endoscopic duodenal-jejunal bypass liner may significantly improve glycemic control and weight loss in patients with poorly controlled type 2 diabetes and obesity.

At one year, HbA1c levels dropped by 1.10% in the DJBL group, compared to just 0.28% in the sham group (p=0.0004).
Patients with HbA1c ≤ 7% more than tripled in the DJBL group (28.3% vs. 9.4%, p=0.0003).

Consider DJBL for selected patients as it may enhance weight loss and glycemic outcomes.

Device-related serious adverse event rate was 9.4%, with specific concerns being intolerance (3.7%) and hemorrhage (2.8%).

Journal Article by Thompson CC, Jirapinyo P (…) Schauer P et 11 al. in Ann Surg

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