Multimodal prehabilitation may enhance baseline immune function in patients before abdominal cancer surgery, but its effect on postoperative immune outcomes appears limited.

• In a study of 130 patients (102 prehabilitation, 28 control), prehabilitation reduced pro-inflammatory cytokines and increased IL-10 levels.
• No significant immune function differences were noted on postoperative day 1 between groups.

This suggests prehabilitation might optimize pre-surgical readiness, but benefits for postoperative immune response may not be substantial.