Splenectomy shows variable success across indications in hematologic cancers.

• Overall 30-day complication rate was 49%, with 22% being severe.
• Success rate was 91.7% for bridge-to-transplant, but only 38.5% for transfusion independence in lymphoid patients.

Surgeons should evaluate the indication for splenectomy carefully, as outcomes differ significantly based on underlying conditions.

• Myeloid patients had a higher complication rate at 65.5% compared to 46.4% in lymphoid patients.