Genomic Insights Enhance Gastric Cancer Outcome Predictions

Molecular profiling of gastric cancer tumors can improve risk stratification for recurrence post-surgery.

In a study of 438 patients, 179 experienced recurrence after resection.
Alterations in the KRAS gene (HR 1.54) and PIK3CA (HR 2.15) were linked to poorer disease-free survival.
Patients with hematogenous recurrence had significant chromosomal instability, suggesting personalized surveillance may be beneficial.
Genomic stability was associated with bone metastases, indicating histological types may guide treatment strategies.

Journal Article by Coffey MR, Xu J (…) Strong VE et 13 al. in JAMA Surg

read the whole article in JAMA Surg

open it in PubMed

Summaries are written to help you decide what to read. They do not replace the full paper.

Free · 5 minutes a day

Get every new paper in Upper Gastrointestinal Tract.

Plus the Daily Selection: the five most relevant papers of the day, each cut to its key points.

The latest stitches

Surg Endosc22 Oct 2026

Tubeless ERAS shortened stay after gastric cancer surgery

A tubeless recovery strategy after laparoscopy-assisted gastrectomy was associated with a shorter hospital stay and better early quality of life in selected non-high-risk patients.

Ann Surg Oncol20 Oct 2026

Robotic Esophagectomy: More RLN Nodes, More Complications

After neoadjuvant therapy for esophageal cancer, robotic surgery more often included left recurrent laryngeal nerve (RLN) node dissection and retrieved more nodes there—but was associated with more overall complications.

Surg Endosc20 Oct 2026

ICG mapping linked to longer gastric cancer survival

In a meta-analysis of 7,518 patients, ICG-guided lymphadenectomy was associated with better 3- and 5-year survival and greater node yield—but the evidence does not establish causation.

All papers in Upper Gastrointestinal Tract →