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Upper Gastrointestinal Tract ·

Elevated Serum IL-10 Levels Linked to Poor Survival in Esophageal Cancer

High pre-treatment serum interleukin-10 levels are associated with significantly worse overall survival in patients with esophageal squamous cell carcinoma treated with chemoradiotherapy.

  • 1-year overall survival rates were 85% in low IL-10 patients versus 56% in high IL-10 patients; 3-year rates were 50% versus 33%.
  • Both advanced cancer stage and high IL-10 levels independently predicted shorter survival.

Surgeons might consider serum IL-10 level testing for better risk stratification and to inform potential immunomodulatory treatment decisions.

Journal Article by Lo CM, Huang DKR (…) Li SH et 5 al. in Ann Surg Oncol

© 2026. The Author(s).

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