Significant variations in hospital performance after colorectal cancer surgery were observed in a Dutch population-based study. The study analyzed data from over 44,000 colorectal cancer patients and found that two hospitals performed worse than expected in terms of 90-day mortality, while significant outliers were observed for anastomotic leakage in both colon cancer and rectal cancer […]
Author: STITCHES Newsletter
Prophylactic Hyperthermic Intraperitoneal Chemotherapy Improves Prognosis in CT4N0-1M0 Colorectal Cancer
A propensity score matching study analyzed 220 colorectal cancer patients undergoing treatment in China. Prophylactic hyperthermic intraperitoneal chemotherapy (HIPEC) was associated with improved 3-year disease-free survival (DFS) compared to no HIPEC (HR 0.43). However, this benefit was not observed in patients with CT4N2M0 cancer. Laparoscopic surgery followed by HIPEC did not increase the risk of […]
Negative Prognostic Impact of Splenic Vein Involvement in Resectable Pancreatic Body or Tail Cancer
Patients with resectable pancreatic body or tail cancer who have splenic vein (SPV) involvement, particularly radiological SPV encasement, experience significantly worse overall survival (OS) and recurrence-free survival (RFS). Independent poor prognostic factors include higher pre-operative carcinoembryonic antigen levels, larger tumor size, pathological SPV invasion, and non-completion of adjuvant therapy. Multidetector-row computed tomography shows relatively high […]
Limited Pain Benefit: Epidural vs. Intravenous Analgesia after Open Hepatectomy
Patient-controlled epidural analgesia (PCEA) did not significantly improve postoperative pain during ambulation compared to intravenous patient-controlled analgesia (IV PCA) following open hepatectomy. There was a small difference in pain scores on postoperative day 2, but it did not meet the pre-specified definition of clinical significance. PCEA was safe with a low incidence of epidural failure […]
Development of Pancreatic Surgery Composite Endpoint (PACE) Enables Lower Sample Sizes and Enhanced Feasibility in Future Trials
Researchers developed and validated a new clinically relevant endpoint, Pancreatic Surgery Composite Endpoint (PACE), for pancreatic surgery. PACE incorporates postoperative pancreatic fistula, post-pancreatectomy hemorrhage, reoperation, and reinterventions. It demonstrated high predictive value for prolonged length of hospital stay (LOS) and mortality in both the development and validation cohorts. PACE allowed for significant reduction in sample […]
Benchmarking Hepatectomy in Intrahepatic Cholangiocarcinoma
Researchers identified benchmark values for hepatectomy in intrahepatic cholangiocarcinoma (ICC) across international institutions. Out of 1,193 patients, 600 (50.3%) were included in the benchmark group. The benchmark values encompassed criteria such as lymph node retrieval, blood loss, transfusion rate, operative time, achievement rates for postoperative outcomes, resection margin, complications, mortality, and hospital stay. Establishing these […]
Early antibiotic treatment is superior to observation for avoiding surgical exploration in acute appendicitis
Acute appendicitis patients were randomly assigned to receive either antibiotic treatment with active observation or classic observation without antibiotic treatment. The study found that early antibiotic treatment was more effective in avoiding surgical exploration and appendectomy compared to the observation group. The antibiotic group had a lower rate of appendectomy at the first hospital stay […]
Improved Predictive Value: GLIM Criteria and HGS Test in Overweight Colorectal Cancer Patients
The retrospective study, which enrolled 850 overweight colorectal cancer patients, found that the incidence of malnutrition was 12.4% in the GLIM group and 6.4% in the HGS-GLIM group. Both malnutrition groups had a significantly higher incidence of complications compared to the control group. Patients in the HGS-GLIM-malnutrition group had worse overall survival and disease-free survival. […]
Low Physical Activity Linked to Postoperative Outcomes in Major Abdominal Cancer Surgery
According to a single-center prospective cohort study, physical activity levels are far from optimal following major abdominal cancer surgery. The study found that postoperative physical activity was low, with a median daily step count ranging from 71 steps on the first postoperative day to 918 steps on the seventh day. Furthermore, the study identified several […]
Frailty Index in Colorectal Cancer: Assessing Surgical Complications and Prognosis
Frailty Index (FI) is a comprehensive tool for assessing frailty in the elderly population with colorectal cancer (CRC). This review evaluates methods for frailty assessment and presents modifications of the FI to accurately evaluate surgical complication risk and prognosis in CRC patients. The research findings highlight the FI’s role in predicting surgical complications, postoperative recovery, […]