Colorectal cancer, a common neoplasm, is increasing in developing countries due to the adoption of Western dietary and lifestyle habits. However, mortality rates have been decreasing in countries with effective prevention and treatment strategies. Routine screenings, improved imaging techniques, surgical advancements, and advancements in chemotherapy and radiation have contributed to earlier detection, accurate staging, and […]
Author: STITCHES Newsletter
Early Onset Pancreatic Cancer Burden Increasing Worldwide, Especially in Asia and Eastern Europe
Early-onset pancreatic cancer (EOPC) in younger populations is characterized by poor differentiation and is increasing globally. According to the Global Burden of Disease Study, there were 36,852 new cases and 32,004 deaths from EOPC in 2019. East Asia had the highest number of cases, while Central and Eastern Europe had notably high burden. Incidence, mortality, […]
Body fat mass loss after radical resection for pancreatic ductal adenocarcinoma predicts poor prognosis
Body fat mass loss was analyzed in patients undergoing radical resection for pancreatic ductal adenocarcinoma (PDAC) using bioelectrical impedance analysis. The study found that a body fat mass loss of ≥14% one month after surgery was associated with a poor prognosis. Lymph node metastasis and non-adjuvant chemotherapy were also identified as independent poor prognostic factors. […]
Opoid-Free Analgesia Leads to Reduced Pain Severity and Risk of Side Effects After Surgery
Patients receiving opioid-free analgesia after surgery experience lower pain severity and decreased risk of side effects compared to those prescribed opioids, according to a multispecialty, prospective cohort study in 25 countries. The study involved 4273 patients from 144 centers, with 30.7% receiving opioid analgesia at discharge. The findings emphasize the need to routinely adopt opioid-free […]
Frailty Score Correlates with Surgical Outcomes in Optimization Before Surgery
Researchers investigated the correlation between frailty score, pre-surgical optimization, and surgical outcomes in frail patients undergoing optimization before surgery. A retrospective study was conducted on patients referred to the surgical optimization clinic and assessed for frailty, and outcomes were evaluated based on whether they proceeded to surgery or had their surgery cancelled or delayed. The […]
Majority of Variation in Lymph Node Assessment for Colon Cancer Linked to Non-modifiable Tumor Factors
Researchers investigated the factors contributing to variation in lymph node assessment for colon cancer and found that non-modifiable tumor factors were responsible for the majority of variation. A dataset of over 280,000 patient records from 15,000 surgeons across 1,200 facilities was analyzed. The achievement of the 12 lymph node standard was high at 90.3%. Factors […]
Higher 30-day surgical complications observed in Asian Americans after esophagectomy
Asian Americans face higher 30-day surgical complications following esophagectomy compared to Caucasians, according to a retrospective analysis of the ACS-NSQIP database. The study found that Asian Americans had a greater likelihood of pulmonary complications, particularly pneumonia, renal dysfunction, including progressive renal insufficiency, and bleeding events. They also had a longer length of stay. These findings […]
Short-Term Metabolic Improvements Following Roux-en-Y Gastric Bypass
The study investigated the metabolic changes and physiological factors mediating the effects of Roux-en-Y gastric bypass (RYGB) surgery in obese patients. Results showed that insulin concentrations decreased significantly after the surgery, along with improvements in weight loss and insulin sensitivity. Additionally, triglycerides, remnant cholesterol, lactate, glycoprotein acetyls, and certain amino acids decreased post-surgery. The study […]
The Obesity Epidemic: Misconceptions and Harmful Beliefs
The CDC’s recent statements on obesity causing metabolic syndrome and attributing it to individual behavior are contested. Bariatric surgery outcomes challenge the direct link between obesity and diabetes suggested by the CDC. The rise in diabetes rates from 2004 to 2012 contradicts behavior-based explanations. The study emphasizes the need for a nuanced understanding of obesity […]
The Effect of Diet Composition on Post-operative Outcomes of Roux-en-Y Gastric Bypass in Mice: Key Findings
Regardless of diet, Roux-en-Y gastric bypass (RYGB) led to significant reductions in body weight, fat mass, and lean mass. RYGB and high-fat diet (HFD) independently affected bone mineral density and vitamin D levels. HFD after RYGB posed a significant health risk, impairing improvements to dyslipidemia, non-alcoholic fatty liver disease (NAFLD), and fibrosis. The study suggests […]