The study aimed to evaluate the role of immunocyte-derived ratios (IDRs) as potential markers for postoperative recovery of gastrointestinal function after colorectal cancer surgery. The retrospective analysis of 260 patients revealed a positive correlation between IDRs (systemic immune-inflammation index, neutrophil-to-lymphocyte ratio, platelet-to-lymphocyte ratio) and the i-feed score, indicating improved gastrointestinal motility. IDRs, along with other […]
Author: STITCHES Newsletter
Fredet’s Fascia: Implications for Safer Right Hemicolectomies in the CME Era
The study reviewed medical literature to assess the use and clinical significance of Fredet’s fascia in complete mesocolic excision (CME) for right-sided colon adenocarcinoma. The results showed limited utilization of the term “Fredet’s fascia” in English medical literature and conflicting definitions and boundaries. The researchers emphasized the importance of understanding Fredet’s fascia in surgical procedures […]
The Role of Adipose Tissue Mesenchymal Stem Cells in Preventing Anastomotic Leak in Colonic Surgery
Adipose tissue-derived mesenchymal stem cells (ADMSCs) were investigated for their potential in reducing inflammation and preventing anastomotic leak in rats with inflammatory bowel disease. Rats were divided into four groups, and those with induced intestinal inflammation were treated with ADMSCs prior to surgery. The study found that ADMSCs effectively attenuated inflammation and significantly reduced the […]
Defining Success in Colorectal Peritoneal Metastasis Surgery: International Consensus and Improved Survival
An international consensus has been reached on the definition of textbook oncologic outcomes (TOO) in cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) for colorectal peritoneal metastasis. The TOO parameters for CRS/HIPEC in this context include absence of certain complications, achievement of complete cytoreduction, and no contraindications for chemotherapy. A study cohort of 251 patients […]
Robotic Resection for Perihilar Cholangiocarcinoma Shows Promising Short-term Outcomes
Robotic resection for perihilar cholangiocarcinoma is a safe and feasible approach with acceptable short-term clinical and oncological outcomes. In a multicenter study of 38 patients, the majority had Klatskin type-3 tumors. The median age was 72 years, and most patients underwent preoperative biliary drainage. The procedure had a median operative time of 481 minutes and […]
Combined use of tumor markers improves prognostic accuracy in gastric cancer
This study evaluated the combined use of three tumor markers (CEA, CA72-4, and CA19-9) for prognostic assessment in gastric cancer patients. Data from 1,966 patients who underwent curative gastrectomy were analyzed, and hazard ratios were calculated. The results showed that the combined use of tumor markers significantly improved prognostic accuracy compared to using a single […]
Drug Response Heterogeneity Found in Patients Undergoing CRS/HIPEC for Nongynecologic Cancers
Among patients undergoing cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) for nongynecologic cancers, intra- and interpatient drug response heterogeneity was observed. Researchers generated patient-derived tumor organoids (PDTOs) and conducted in vitro drug screens to assess drug response. PDTOs were successfully generated from 13 out of 23 patients, and drug screen results were obtained in as […]
Perioperative Chemotherapy Linked to Superior Overall Survival in Patients with Colorectal Liver Metastases
Perioperative chemotherapy is associated with superior overall survival in patients with synchronous colorectal liver metastases. Resection of both the primary and metastatic sites is linked to better overall survival. The study also found that patients who received perioperative chemotherapy had significantly longer overall survival compared to those who had preoperative or postoperative chemotherapy alone. Additionally, […]
Optimal surgical techniques and accumulation of cases lead to improved outcomes in robotic pancreaticoduodenectomy
Researchers from a Japanese single center experience studied 76 cases of robotic pancreaticoduodenectomy (RPD) and found that the mean operation time decreased over time despite the involvement of new surgeons. They also observed a decrease in major complications from the early competency phase to the mastery phase. Additionally, optimization of the procedure, specifically the hanging […]
Comparison of Short-Term Outcomes of Esophagojejunal Anastomotic Techniques during Laparoscopic Total Gastrectomy
Based on a network meta-analysis of 20 studies involving 3,177 patients, the study found that different esophagojejunal anastomotic techniques during laparoscopic total gastrectomy (LTG) for gastric cancer have comparable rates of anastomotic leakage and stenosis. No significant differences were observed in anastomotic bleeding, operative time, time to soft diet resumption, pulmonary complications, hospital length of […]