Calcium channel blockers (CCB) were found to be associated with improved overall survival in pancreatic cancer patients undergoing neoadjuvant chemotherapy and resection. A retrospective study of 6,223 patients showed that CCB prescription was specifically beneficial in the subgroup receiving neoadjuvant chemotherapy, reflecting the chemosensitizing effect observed in laboratory studies. These findings suggest that patients receiving […]
Author: STITCHES Newsletter
Higher likelihood of non-home discharge in pancreatic cancer patients aged 80 years and above
In a study analyzing pancreatic cancer patients aged 80 years and above, it was found that non-home discharge after pancreatoduodenectomy (PD) was more than twice as likely to occur in this age group compared to those aged 65-79 years. Comorbidity factors such as COPD, hypertension, heart failure, and lower preoperative albumin were significantly associated with […]
The impact of diabetes mellitus on outcomes in patients undergoing surgical pancreatectomy for pancreatic diseases
A retrospective analysis of 370 patients who underwent pancreatic resection surgery in Austria revealed that the incidence of postoperative diabetes mellitus (postopdm) was 29%. Postopdm occurred significantly more frequently in patients with malignant pancreatic diseases compared to benign diseases (31.3% vs. 16.7%). The study highlights the prominence of diabetes mellitus as a risk factor for […]
Age-Dependent Disparities in General Surgery Outcomes: Variations in Hospital Performance
Hospital performance for general surgery varies between younger and older adults, with in-hospital mortality rates showing significant differences. Failure-to-rescue rates drive the variation in older adults, while both complication and failure-to-rescue rates contribute to high mortality rates in younger adults. Correlations between observed-to-expected mortality ratios suggest distinct hospital performance in each age group. Low-mortality hospitals […]
Portal Hypertension Assessment Crucial for Hepatocellular Carcinoma Resection Decision
Indirect signs of portal hypertension (pht) don’t raise complications risk in hepatocellular carcinoma (HCC) patients undergoing liver resection (LR). However, in patients with hepatic venous pressure gradient (HVPG) ≥10 mmHg, LR significantly increases overall morbidity and liver-related complications risk. Transjugular HVPG assessment is crucial for LR decisions, with a minimally invasive approach showing favorable outcomes, […]
Pathological Response is not a Reliable Surrogate for Overall Survival in Neoadjuvant Studies for Esophageal Cancer
The study evaluates the validity of using pathological response as a surrogate marker for overall survival (OS) in neoadjuvant studies for esophageal cancer. A meta-analysis comprising 40 trials and 55,344 patients shows that the surrogacy between pathological complete response (PCR) and OS is moderate. The study establishes a lack of surrogacy at the trial level […]
Accurate Prediction of Anti-TNF Treatment Failure in Perianal Crohn’s Disease Using MRI-Based Model
Researchers developed an MRI-based prediction model for anti-TNF treatment failure in perianal Crohn’s disease. The model, based on clinical and radiologic parameters, accurately predicts the likelihood of treatment failure and outperforms existing imaging-based indices. The study included 221 patients, with treatment failure occurring in 46% of cases. The prediction model included age at diagnosis, time […]
Predictive factors for successful same-day discharge following minimally invasive colorectal surgery
A prospective cohort study conducted at a tertiary colorectal center aimed to identify predictive factors for successful same-day discharge following minimally invasive colorectal surgery. Out of 175 patients, 161 (78.5%) were discharged on the day of surgery without complications, while 44 (21.5%) experienced same-day discharge failure. Factors associated with failure included higher comorbidities, prolonged post-anesthesia […]
Nonoperative Management Shows Promising Results for Anal Adenocarcinoma
Anal adenocarcinoma can be effectively treated with total neoadjuvant therapy and nonoperative management, according to a retrospective analysis conducted at a comprehensive cancer center. The study included 70 patients, out of which 77% received neoadjuvant therapy. Patients who underwent total neoadjuvant therapy had a higher proportion of successful watch-and-wait management compared to those who received […]
Temporary Stoma Does Not Impact Long-Term Functional Outcomes in Rectal Cancer Patients
Rectal cancer patients who undergo surgical resection with or without a temporary stoma were compared in terms of long-term functional outcomes. The study, conducted at seven Dutch hospitals with 656 patients, found that those with a temporary ileostomy experienced less constipation but more fecal incontinence and major low anterior resection syndrome compared to those without […]