A systematic review and meta-analysis of 746 patients revealed that cytoreduction and hyperthermic intraperitoneal chemotherapy (CRS/HIPEC) significantly enhances median overall survival to 32.3 months, compared to 14.5 months with systemic chemotherapy alone. In patients undergoing complete cytoreduction, the study reported a major morbidity rate of 20.7% and a mortality rate of 1.7% associated with CRS/HIPEC. […]
Category: Cytoreductive Surgery & Peritoneum
Screening improves survival outcomes in colorectal peritoneal metastases.
Analysis of 2,773 colorectal peritoneal metastasis patients revealed that those diagnosed through screening had significantly better survival rates and more often received curative treatment. Specifically, 7% were screen-detected, with a median overall survival of 20 months compared to 10.8 months for clinically detected patients. Additionally, 28% of screen-detected patients underwent cytoreductive surgery with hyperthermic intraperitoneal […]
Enhanced Recovery After Surgery Program Lowers Hospital Stays
A multidisciplinary Enhanced Recovery After Surgery (ERAS) program significantly improved compliance and reduced hospital stays for patients undergoing cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (CRS/HIPEC). Compliance with ERAS protocols rose from 32.8% to 70.8%. Concurrently, the median length of stay decreased from 14 to 9 days, with no significant difference in major morbidity or 30-day […]
Hyperthermic Intraperitoneal Chemotherapy Enhances Survival in Gastric Cancer
A meta-analysis of 12 randomized controlled trials involving 1,181 gastric cancer patients demonstrated that hyperthermic intraperitoneal chemotherapy (HIPEC) significantly improved survival rates compared to control groups at 1, 2, 3, and 5 years. The recurrence rates were notably lower in the HIPEC group, and higher disease-free survival rates were also observed. These findings suggest that […]
Circulating biomarkers predict peritoneal metastasis in gastric cancer
A prospective clinical study evaluates the predictive effects of circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) in peritoneal lavage fluid for metachronous peritoneal metastasis (PM) in gastric cancer patients following radical resection. A total of 200 patients will be monitored over two years, with a primary focus on PM incidence one year post-surgery. […]
MRI effectively assesses peritoneal cancer index in patients.
Results indicate that diffusion-weighted MRI (dw-MRI) demonstrates significant accuracy in evaluating the peritoneal cancer index (PCI) in colorectal cancer patients with peritoneal metastases. In a cohort of 87 patients, a strong correlation was found between MRI-derived PCI and histopathology (0.77), with surgical PCI showing excellent agreement with histopathology at 0.87. These findings support MRI’s potential […]
Morphological imaging descriptions boost accuracy in peritoneal malignancy diagnosis
The study identified a high correlation between specific morphological appearances of peritoneal malignancies on imaging and their pathological outcomes. In a cohort of 630 patients, scalloping had a positive pathological incidence of 93.5%, followed by confluent disease at 78.8%, and tumor nodules at 69.6%. The results advocate for routine inclusion of standardized morphological descriptions in […]
PIPAC improves quality of life and survival in cancer treatment
The analysis demonstrated that patients receiving pressurized intraperitoneal aerosolized chemotherapy (PIPAC) experienced significantly more good days and reduced hospital stays compared to those treated with standard therapy (ST). Specifically, PIPAC patients had a median of 181 good days at six months versus 131 days for ST, and an overall survival median of 11.3 months compared […]
Diagnostic laparoscopy shows strong accuracy for cancer treatment selection
A systematic review of 25 studies involving 3,820 patients found that diagnostic laparoscopy (DL) exhibits high diagnostic performance in selecting patients with peritoneal carcinomatosis for cytoreductive surgery and hyperthermic intraperitoneal chemotherapy. The pooled positive predictive value was 93.04%, with sensitivity at 98.26% and specificity at 83.67%. Further analysis identified high accuracy in ovarian cancer cases, […]
Tumor nodules show higher pathology confirmation rates in surgery.
A multicenter study of 707 patients revealed significant variability in surgical peritoneal cancer index (SPCI) recording and lesion pathology confirmation across 10 centers. Notably, ‘tumor nodules’ demonstrated a higher incidence of pathologically confirmed disease, particularly with a lesion score of 2/3 (63.1%) versus 1 (31.5%, p < 0.001). Additionally, the absence of significant differences in […]