Newsletter
Every new paper in this field, in your inbox.
Using intraoperative frozen section analysis during cholecystectomy, surgeons can decide on a single-stage management approach for suspected gallbladder cancer (GBC). A retrospective cohort study of 37 consecutive cholecystectomies found that frozen section analysis had a sensitivity of 100% and a specificity of 100% for detecting…
Conversion surgery significantly improves survival outcomes in patients with positive responses to PD-1/PD-L1 inhibitor-based combined therapy for unresectable biliary tract cancer. Median progression-free survival and overall survival were significantly longer with conversion surgery compared to continued systemic therapy alone. The estimated 3-year survival rates post-surgery…
High-volume and high-performance centers had lower risk-standardized mortality rates for hepato-pancreatobiliary procedures. Redistributing patients based on risk-standardized mortality rate may save more lives compared to volume-based redistribution. These findings suggest that risk-standardized mortality rate may be a superior measure of hospital quality in complex oncologic…
Pathologists developed recommendations based on international consensus to enhance the clinical value of tissue samples in intrahepatic cholangiocarcinoma management. The guidance includes consensus statements on specimen handling, reporting content, and the need for molecular information to guide personalised therapies. These recommendations aim to standardize reporting…
Transarterial chemoembolization (TACE) combined with targeted therapy and immunotherapy (TACE-T-I) shows greater efficacy and safety compared to TACE with targeted therapy alone (TACE-T) in treating unresectable hepatocellular carcinoma (HCC). A meta-analysis of 14 studies with 2144 patients revealed that the TACE-T-I group had higher overall…
Endoscopic ultrasound (EUS) for incidental common bile duct (CBD) dilation revealed that only 8.3% of cases had significant findings. Researchers identified predictors including age ≥70, non-biliary-type abdominal pain, CBD diameter ≥15 mm, and prior ERCP. A novel clinical prediction model was created, scoring age, pain…
Researchers developed and validated machine learning-based predictive models for lymph node metastasis (LNM) in intrahepatic cholangiocarcinoma (ICC) using clinicopathological data from 345 patients. The study used six machine learning algorithms, identifying the Extreme Gradient Boosting (XGB) model as the best, with an average area under…
Modified mesohepatectomy offers a safe and beneficial alternative to trisectionectomy for treating bilobar congenital biliary dilatation. It results in higher residual liver volume, lower parenchyma resection rate, reduced complications, and optimal long-term outcomes, making it a valuable option for patients ineligible for major hepatectomy or…
Imatinib combined with hepatic resection significantly improves overall survival in patients with gastrointestinal stromal tumor liver metastases compared to imatinib monotherapy. Achieving no evidence of disease status through surgical intervention leads to prolonged overall survival, liver-specific progression-free survival, and progression-free survival. Age ≤60 years and…
Transitioning to robotic liver resection in a limited resource setting may offer feasible surgical outcomes, with no conversions to open surgery, low complication rates, and decreased operative time based on a retrospective study of 67 cases. Major hepatectomies and complex procedures were successfully performed, indicating…
