BRAF mutations in colorectal cancer patients with liver metastases are linked to poorer survival outcomes. However, liver resection shows a significant 56% reduction in the risk of death for patients with BRAF-mutated colorectal liver metastases. Surgical intervention offers a clear survival benefit, with a reduced hazard ratio of 0.44 favoring surgery. Review by Petrelli F, […]
Category: HPB & Spleen
Patterns of Lymph Node Metastases in Non-pancreatic Periampullary Cancers
Study identifies variations in lymph node metastases among different non-pancreatic periampullary cancer subtypes. Pancreatobiliary-type ampullary adenocarcinoma had higher lymph node metastasis rates. Distinct patterns of metastases were observed, with certain lymph node stations more frequently affected in different cancer types. Research highlights the need for standardized lymphadenectomy and pathology assessment for improved management of these […]
Tissue Sources for Pancreatic Cancer Organoids
Establishing patient-derived tumor organoids (PDTOs) from endoscopic ultrasound-guided biopsies yields success rates comparable to surgical specimens, offering viable options for personalized medicine in pancreatic cancer. In a meta-analysis of 24 studies, overall success rate was 63%. Pooled success rates for PDTO establishment from endoscopic ultrasound-guided biopsies, percutaneous biopsies, and surgical specimens were 60%, 36%, and […]
Endoscopic Ultrasound-Guided Ablation Outperforms Surgery for Pancreatic Cystic Tumors
Endoscopic ultrasound-guided pancreatic cyst ablation (EUS-PCA) demonstrated superior long-term safety and pancreatic function preservation compared to surgery in selected patients with pancreatic cystic tumors. EUS-PCA group had lower rates of morbidities, adverse events, readmission, and diabetes development, with shorter hospital stay. However, surgery group showed higher complete resolution rate and lower relapse rate. EUS-PCA is […]
External Stents Show Promise in Reducing Postoperative Pancreatic Fistulas
Stent placement following pancreaticojejunostomy did not significantly reduce clinically relevant postoperative pancreatic fistulas (CR-POPFs). However, external stents and placement in patients with ≤3mm main pancreatic duct diameter showed reduced CR-POPFs compared to no stent placement. These findings suggest a potential benefit of external stents in reducing CR-POPFs, especially in patients with undilated pancreatic ducts. Journal […]
Preservation of Caval Flow in Complex Hepatectomy Under Total Vascular Exclusion
Hypothermic liver perfusion during hepatectomy under total vascular exclusion preserving caval flow showed excellent hemodynamical tolerance, with no 90-day mortality and stable hemodynamics. The technique avoids splanchnic congestion and reduces ischemia time, making it a promising approach for patients requiring prolonged vascular control in hepatic surgery. Journal Article by Azoulay D, Salloum C (…) Lim […]
Recalibrated Fistula Risk Score Outperforms Others in Laparoscopic Pancreaticoduodenectomy
External validation and comparison of 3 pancreatic fistula risk scores were performed in 200 laparoscopic pancreaticoduodenectomy patients. The recalibrated updated alternative fistula risk score showed sufficient discrimination and calibration for predicting clinically relevant postoperative pancreatic fistula, with better performance in predicting general postoperative pancreatic fistula than clinically relevant cases. Pancreatic texture, pathology, and duct diameter […]
Postoperative Hyperamylasemia Reduces Pancreatectomy Outcomes
Postoperative hyperamylasemia significantly increases complications and reduces textbook outcomes after pancreatoduodenectomy compared to distal pancreatectomy. Hyperamylasemia is an independent predictor of poorer outcomes in pancreatoduodenectomy patients. This highlights the importance of monitoring amylase levels postoperatively to anticipate potential systemic complications and guide treatment decisions. Journal Article by Radulova-Mauersberger O, Mibelli N (…) Oehme F et […]
Simultaneous Resection of Liver Metastases Combined with HIPEC Improves Clinical Outcomes in Synchronous Colorectal Cancer Liver Metastasis
The study showed that simultaneous resection of liver metastases combined with HIPEC resulted in a significantly higher complete resection rate, total effective rate, and negative change of CEA compared to resection alone. This approach demonstrated superior efficacy in treating synchronous colorectal cancer liver metastases, potentially extending patient survival and improving quality of life. Journal Article […]
Comparable Textbook Outcomes: Open vs Minimally Invasive Hepatectomy for HCC
Patients with hepatocellular carcinoma undergoing minimally invasive hepatectomy (MIH) showed comparable likelihood of achieving textbook outcome in liver surgery (TOLS) compared to open hepatectomy (OH). MIH was associated with a shorter hospital stay, with TOLS incidence similar between the two approaches after propensity score matching. Tumor burden influenced MIH’s TOLS success, highlighting benefits and limitations […]