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Utilizing periarterial and sub-adventitial divestment alongside the triangle operation and RAMPS, researchers achieved R0 resection in locally advanced pancreatic body cancer without compromising oncologic outcomes. The technique, demonstrated in a multimedia article, provides an alternative to morbid arterial resection, ensuring optimal tumor clearance and preserving…
Study compares long-term outcomes of liver transplant (LT) and resection (LR) in patients with multifocal hepatocellular carcinoma (MHCC). LT associated with improved survival over LR, with LT patients more likely to be non-Hispanic white, privately insured, and treated at academic centers. Findings suggest LT may…
Deep learning models applied to prechemotherapy imaging accurately predict response to neoadjuvant chemotherapy in colorectal cancer liver metastases, outperforming clinical models. A study on 95 patients found the deep learning model had an AUC of 0.77, superior to the clinical model's AUC of 0.41, showing…
Identifying predictors of bile leakage after hepatectomy, researchers established criteria for safe early drain removal. Analyzing 351 patients, they found a drainage fluid direct bilirubin level cutoff of 0.16 mg/dl and volume cutoff of 125 ml on postoperative day 2. Patients meeting both criteria had…
Improved systemic therapy has increased long-term survival rates after resection of pancreatic ductal adenocarcinoma. Sex, BMI, tumor markers, and pathological characteristics influence long-term survival. No single factor can predict survival, highlighting the complex interplay between risk, biology, and patient management. A systematic review analyzing 25…
Robotic pancreaticoduodenectomy (RPD) offers similar or superior outcomes compared to open approaches for pancreatic ductal adenocarcinoma (PDAC) treatment. RPD shows reduced blood loss, lower post-operative pain, and shorter hospital stays. Despite similar operative times, RPD yields better oncological results, including margin status and survival rates.…
Patients with "oligo-like liver metastasis" (OLLM) in post-surgical pancreatic cancer have better overall survival after recurrence through surgical intervention. Key factors defining OLLM include long recurrence-free interval, stable disease interval, and fewer recurrent tumors. OLLM patients show significantly improved prognosis compared to non-OLLM patients, suggesting…
Using a machine learning model, researchers accurately predicted liver and/or lung metastasis in colorectal cancer patients, assisting clinical decision-making. A total of 51,265 patients were analyzed, with 15.3% having distant metastasis. The random forest algorithm showed the best predictive ability with high accuracy, AUC, and…
Plasma levels of specific miRNAs and proteins show promise as biomarkers for distinguishing between chronic pancreatitis and pancreatic adenocarcinoma, with high diagnostic performance values. The combination of miRNAs hsa-mir-150-3p, hsa-mir-150-5p, and hsa-mir-214-3p, along with proteins PCDH1 and AMN, could aid in predicting pancreatic adenocarcinoma in…
Survival stratification among pancreatic cancer patients after surgery improved by combining skeletal muscle mass, immune markers, and traditional clinical factors. Nomogram based on muscle mass to BMI ratio and inflammatory markers showed superior predictive accuracy for long-term survival, suggesting potential integration into existing risk assessment…
