Minimum CA19-9 decrease of ≥40% and optimal decrease of ≥60% after induction chemotherapy are independent predictors for prolonged overall survival in patients with locally advanced pancreatic cancer, particularly when CA19-9 levels are elevated at baseline. These thresholds can guide treatment decisions during early response evaluation. Journal Article by Seelen LWF, Doppenberg D (…) Besselink MG […]

Pancreatic cancer surveillance in high-risk individuals led to early diagnosis of pancreatic malignancies and premalignant lesions, with most cases found at baseline. Of the 156 participants with at least a 3-year follow-up or cancer-related events, 9 individuals had malignant or premalignant lesions, demonstrating the feasibility and safety of surveillance in a public healthcare system. Journal […]

Robot-assisted and laparoscopic pancreatoduodenectomy showed similar major morbidity and mortality rates in a pan-European cohort. However, laparoscopic approach was associated with shorter operation time and lower rates of postoperative complications, while robot-assisted approach had lower conversion rates and higher lymph node retrieval. The study highlights the comparable outcomes of both techniques, each with its distinct […]

ABCD1 is identified as a promising diagnostic marker for differentiating solid pseudopapillary neoplasm of the pancreas from other pancreatic neoplasms, including pancreatic neuroendocrine tumors, with exceptional efficacy in immunohistochemical staining. Through a large-scale patient cohort analysis, researchers found that ABCD1 shows high sensitivity (99.10%) and specificity (100%) in distinguishing SPN from other pancreatic tumors, demonstrating […]

High rates of fragmented practice in hepatopancreatic surgery were associated with increased odds of postoperative complications, extended length of stay, 90-day mortality, and lower likelihood of achieving a textbook outcome. This negative impact persisted regardless of surgeon volume and was more pronounced among female surgeons. Treatment by surgeons with higher fragmented practice also led to […]

Patients with locally advanced pancreatic cancer (LAPC) who underwent resection following induction therapy showed comparable postoperative pancreas-specific complications, mortality, disease-free interval, and overall survival rates as those with (borderline) resectable pancreatic cancer ((B)RPC). Laparoscopic patients had a higher rate of delayed gastric emptying post-surgery compared to (B)RPC patients, but overall outcomes were similar between the […]

Survival outcomes of incidental intrahepatic cholangiocarcinoma patients who did not undergo lymph node dissection were similar to those who underwent dissection in T1 stage, but poorer in T2 and T3+4 stages. Patients incidentally diagnosed with T2 or above T stage may benefit from additional lymph node dissection based on the study’s retrospective analysis of 284 […]

After analyzing 26 studies with 4055 patients, the pooled incidence of nonalcoholic fatty liver disease after pancreatectomy was 29%. Female sex, pancreatic ductal adenocarcinoma, portal vein or superior mesenteric vein resection, dissection of nerve plexus around the superior mesenteric artery, and adjuvant chemotherapy were significantly associated with nonalcoholic fatty liver disease. Pancreatic enzyme replacement therapy […]

Researchers introduced an inferior vena cava (IVC) priority approach in laparoscopic caudate lobectomy, studying 21 patients with caudate hepatic tumors. Those who underwent the pure IVC approach had shorter hepatic pedicle clamping and operation times as well as shorter hospital stays compared to the combined approach group. The technique proved safe and feasible, emphasizing the […]