An antimicrobial stewardship program tailored for pancreatic surgery significantly reduced surgical site infections (SSIs) linked to colonized bile. In a study of 1,638 pancreatoduodenectomies, the program cut overall SSI rates by 34% and superficial SSI rates by 59%. Importantly, the predictive value of intraoperative bile culture for SSIs diminished post-implementation, underscoring the efficacy of personalized […]

Trisectionectomies (TS) dramatically enhance overall and disease-free survival for patients with Bismuth-Corlette type II and III perihilar cholangiocarcinoma, outperforming standard hemihepatectomies (EH). In a study of 443 patients, TS improved overall survival to 52.4 months compared to 31 months for EH. Although TS resulted in higher rates of liver failure, morbidity and mortality rates remained […]

A predictive model effectively identifies patients with non-functioning pancreatic neuroendocrine tumors (NF-PanNETs) at high risk for early recurrence (ER). Developed from a cohort of 496 patients, the model leverages preoperative clinical, pathological, and imaging variables, achieving an AUC of 0.91 in training and 0.84 in validation. Neoplastic venous thrombosis emerged as the strongest recurrence predictor, […]

With primary liver cancer often diagnosed too late for surgery, systemic treatments are becoming vital. The review highlights advances in molecular targeted therapies and immunotherapies, including cutting-edge combinations that suppress disease progression, extend survival, and enhance quality of life for patients. Challenges in implementation remain, but the evolving landscape of systemic therapies promises new avenues […]

Despite advancements in surgical techniques, the incidence of postoperative pancreatic fistula (POPF) after pancreatoduodenectomy has risen, increasing from 13.3% in 2018 to 15.7% in 2023. Racial disparities impact outcomes, with Asian and other non-White patients facing higher risks. Conversely, preoperative chemotherapy appears to reduce POPF likelihood. This analysis, based on a large cohort of 28,100 […]

A novel prognostic score effectively stratifies hepatocellular carcinoma patients with microvascular invasion based on early recurrence factors. Evaluating 265 patients, it incorporates serum alpha-fetoprotein levels, hepatitis B e antigen status, and presence of satellite nodules. Higher scores correlate with significantly lower three-year recurrence-free and overall survival rates. The findings underscore the score’s predictive power beyond […]

Laparoscopic hepaticoduodenostomy (LHD) has emerged as a viable alternative to traditional Roux-en-Y hepaticojejunostomy for bilioenteric reconstruction. In a study involving 125 patients, LHD was successfully performed in 91.5% of cases with cholangiocarcinoma and 54.9% for benign biliary strictures. Key metrics included a mean operative time of 210 minutes, a hospital stay averaging six days, and […]