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Researchers identified embryologically defined peripancreatic compartments and fusion planes, demonstrating distinct pancreatic compartments with potential significance in pancreatic cancer resection. Through manual preparation of body donors, they tracked mesogastria remnants and peripancreatic spaces sealed off from surrounding units. By following avascular embryologic fusion planes, they…
Researchers developed and validated a prognostic nomogram for intrahepatic cholangiocarcinoma, incorporating hepatitis C, CA19, tumor extent, tumor size, LVI, positive lymph nodes, and TMB as predictive factors. The nomogram demonstrated high accuracy in predicting patient outcomes with a c-index of 0.78 for the training set…
Neoadjuvant transarterial chemoembolization (TACE) in upfront resectable large hepatocellular carcinoma (HCC) did not significantly impact long-term outcomes overall, but showed improved overall survival in HCC ≥10 cm and a trend in single HCC and after portal vein embolization/ligation. TACE should not be routinely performed in…
Patients with high-grade liver injuries and contrast extravasation managed initially with observation versus interventional radiology were compared. While interventional radiology patients had a higher rate of operation, there were similar rates of liver-related complications and mortality between the two groups. The results suggest that initial…
Somatic mutational analysis from EUS-guided biopsies of pancreatic adenocarcinoma showed a high yield and comparable impact to that of surgical resection. EUS sampling had a yield of 89.5%, with over a quarter carrying actionable mutations and one in six having treatment impacted by mutational analysis.…
Patients with resectable/borderline-resectable pancreatic cancer underwent neoadjuvant chemotherapy with gemcitabine plus nab-paclitaxel or gemcitabine plus S-1. While there was no significant difference in 2-year progression-free survival rates between the two groups, the gemcitabine plus nab-paclitaxel regimen showed a longer median progression-free survival. Adverse events, completion…
Researchers reviewed the latest advancements in the diagnosis and management of hepatic adenomas. They classified it into 8 subtypes based on molecular pathology, each with unique characteristics and risks of malignant transformation. Larger adenomas over 5 cm have a higher risk of bleeding and malignancy…
Robotic liver resection for huge hepatocellular carcinoma (HCC) is feasible, with comparable perioperative outcomes to regular HCC cases. A single-surgeon study of 337 patients showed no significant differences in major perioperative indicators between regular and huge HCC groups. Effective perioperative risk management suggests potential benefits…
Patients with preoperative anemia undergoing curative-intent resection for gastroenteropancreatic neuroendocrine tumors (GEP-NETs) had higher rates of major complications and poorer long-term outcomes. Anemia was associated with worse overall survival, while postoperative transfusions were linked to lower overall survival and recurrence-free survival rates. Preoperative anemia affected…
Antecolic reconstruction after pancreaticoduodenectomy significantly increases the risk of delayed gastric emptying compared to transmesocolic reconstruction. Patients who underwent antecolic reconstruction had a higher incidence of severe delayed gastric emptying and a 2-fold increase in severe cases. Tmc reconstruction may be superior in minimizing the…
