Characterization of the tumor microbiome in intrahepatic cholangiocarcinoma revealed a higher diversity than in adjacent nontumoral liver tissues, with increased abundance of specific bacterial groups. Higher tumor microbial diversity was linked to lymph node metastasis and predicted shorter overall and recurrence-free survival. A risk score formulated from 11 selected bacteria could independently predict overall survival, […]
Category: HPB & Spleen
Reduced Gas Embolism with Low Pneumoperitoneum Pressure in Laparoscopic Liver Resection
Low pneumoperitoneum pressure reduces the incidence and duration of severe gas embolism during laparoscopic liver resection, leading to steadier hemodynamics, vital signs, and overall improved patient outcomes. Group L, with low pressure, showed significantly fewer cases of severe gas embolism, shorter duration of embolism episodes, and less physiological stress compared to Group S with standard […]
Non-Therapeutic Laparotomy in Locally Advanced Pancreatic Cancer has Limited Impact on Survival
Non-therapeutic laparotomy occurred in 28.2% of patients with locally advanced pancreatic cancer after induction (m)folfirinox, with no significant difference in overall survival or palliative therapy compared to those who did not undergo surgery. The 5-year overall survival rates were 11.4% for group a (laparotomy), 8.7% for group b (no surgery), and 24.7% for group c […]
Predictors of Perioperative Complications in Open Biliary Bypass for Malignant Biliary Obstruction
Patients undergoing open biliary bypass for malignant biliary obstruction face significant perioperative risks. A multicenter study identified preoperative cholangitis, longer surgery duration, and elevated serum bilirubin levels as predictors of complications. Hazard ratios revealed 2.49 times higher risk with cholangitis, 2.47 times higher risk with longer surgery, and a 14% increase in risk per 1 […]
Comparable Efficacy of Lumen-Apposing Metal Stents and Plastic Stents for Walled-Off Necrosis Drainage: PROMETHEUS Study
This multicenter, randomized trial compared lumen-apposing metal stents (LAMS) and double-pigtail plastic stents (DPS) for walled-off necrosis drainage. Results showed similar short and long-term clinical success rates between both groups. LAMS had a shorter procedure duration, similar hospital stay, and safety profile compared to DPS, with a lower incidence of de novo fever. Overall, the […]
Virtual Reality with Head-Mounted Display Improves Decision-Making in Hepatic Surgery Training.
A study compared virtual reality with head-mounted display (VR-HMD), on-screen 3D visualization, and 2D computed tomography for hepatic surgery training. Results showed higher accuracy and faster responses in the VR-HMD and 3D groups compared to the 2D group. Both VR-HMD and 3D were equally effective, indicating VR-HMD’s usefulness in determining liver anatomy and tumor involvement […]
Comparison of Laparoscopic and Open Pancreatectomy for Solid Pseudopapillary Neoplasms
Outcome and survival were similar between laparoscopic and open pancreatectomy for solid pseudopapillary neoplasms in 102 patients. Laparoscopic approach was associated with lower blood loss, shorter surgery duration, fewer complications, and smaller tumor size for specific procedures. Recurrence rates were low and unrelated to the surgical approach. Laparoscopic pancreatectomy is safe and effective but should […]
Identification of Predictive Factors for Clinically Relevant Postoperative Pancreatic Fistula
Researchers identified that a combination of inflammatory parameters and drainage fluid culture results on postoperative day 3 can accurately predict the risk of clinically relevant postoperative pancreatic fistula (CR-POPF) after pancreatectomy. Factors such as drainage fluid amylase level ≥722 IU/L, culture positivity, and neutrophil count ≥5473/mm significantly influence the onset of CR-POPF. A predictive model […]
Establishment of Patient-Derived Organoids from Pancreatic Cancer Biopsies for Personalized Medicine
A patient-derived organoid platform was successfully established from endoscopic ultrasound-guided fine needle biopsies of pancreatic ductal adenocarcinoma, with a high success rate and fast turnaround time. The organoids showed high concordance with the original tumor tissues, revealed more genetic alterations, and accurately predicted drug sensitivity in clinical correlation. This approach enables timely personalized medicine by […]
Preoperative Chemoradiotherapy Reduces Pancreatic Fistula Risk
Preoperative chemoradiotherapy, but not chemotherapy, was found to be associated with a reduced risk of postoperative pancreatic fistula in patients undergoing pancreatoduodenectomy for pancreatic ductal adenocarcinoma. Out of the 2,019 patients included in the study, postoperative pancreatic fistula occurred in 8.3% after immediate surgery, 4.2% after preoperative chemotherapy, and 2.0% after preoperative chemoradiotherapy. These findings […]