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In a nationwide study on resectable pancreatic ductal adenocarcinoma (PDAC), researchers found that elevated preoperative CA19-9 levels (≥500 U/ml) significantly reduced overall survival after upfront resection, unlike Eastern Cooperative Oncology Group performance status. This highlights the prognostic value of incorporating CA19-9 into the preoperative staging…
Pediatric pancreatic surgery, analyzed in a 73-patient study, demonstrated safety and effectiveness. Distal pancreatectomy was the most common procedure, addressing indications like chronic pancreatitis, tumors, and trauma. Postoperative morbidity occurred in 34.2%, with no 90-day mortality. The 5-year overall survival was 90.5%, emphasizing the feasibility…
EUS plays a crucial role in the liver transplantation (LT) workup for patients with unresectable perihilar cholangiocarcinoma (pCCA). In a nationwide study, EUS identified malignant nonregional lymph nodes (LNs) in 4% of patients potentially eligible for LT. Surgical staging confirmed malignancy in 14% of patients…
Endoscopic ultrasound-guided hepaticogastrostomy (EUS-HGS) is associated with higher rates of adverse events and recurrent biliary obstruction compared to antegrade stenting followed by EUS-HGS (EUS-HGAS) in patients with malignant distal biliary obstruction. However, EUS-HGAS significantly extends the time to recurrent biliary obstruction, potentially benefiting patients with…
Researchers proposed a novel predictive model based on preoperative imaging parameters and stapler handling for postoperative pancreatic fistula (POPF) in distal pancreatectomy. Among 81 patients who underwent the procedure using a linear stapler, 38.2% developed POPF. The model identified computed tomography-measured pancreatic thickness and pancreas-to-muscle…
High acinar pancreatic content on preoperative CT scans is associated with increased risk of postpancreatectomy acute pancreatitis and pancreatic fistula formation. A simple radiological score combining pancreatic density, wirsung caliber, and pancreatic thickness predicts patients at higher risk for these complications, with male gender and…
Patients with modest radiologic response to neoadjuvant treatment (NAT) for pancreatic cancer face operative eligibility uncertainties. A novel Sialyl-Lewis Antigen-related Index (SLE Index) combining CA19-9 and Dupan-II reveals significant prognostic value. An SLE Index below 45.25 correlates with favorable disease-free survival, proving superior in predicting…
Researchers analyzed data from 190 post-pancreaticoduodenectomy patients with upper gastrointestinal symptoms and found a 10.5% incidence of marginal ulcers. Factors associated with an increased risk of marginal ulcers included advanced age, alcohol consumption, smoking, longer surgery time, and postoperative bleeding, while regular use of antacids…
The study compared endoscopic and surgical treatment in acute necrotizing pancreatitis, showing that endoscopic treatment resulted in lower peri-interventional morbidity, shorter hospital stays, and lower mortality rates. Endoscopic treatment also led to better long-term outcomes with reduced renal insufficiency, ventilation dependency, and recurrence rates, along…
Triple therapy regimen (ICI+TKI+TACE) showed higher disease control rate and overall survival compared to other treatments in patients with advanced hepatocellular carcinoma. It had a higher disease control rate than ICI+TACE, ICI+TKI, and TKI+TACE, as well as improved overall survival compared to ICI+TKI and TKI+TACE.…
