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Calcium channel blockers (CCB) were found to be associated with improved overall survival in pancreatic cancer patients undergoing neoadjuvant chemotherapy and resection. A retrospective study of 6,223 patients showed that CCB prescription was specifically beneficial in the subgroup receiving neoadjuvant chemotherapy, reflecting the chemosensitizing effect…
In a study analyzing pancreatic cancer patients aged 80 years and above, it was found that non-home discharge after pancreatoduodenectomy (PD) was more than twice as likely to occur in this age group compared to those aged 65-79 years. Comorbidity factors such as COPD, hypertension,…
A retrospective analysis of 370 patients who underwent pancreatic resection surgery in Austria revealed that the incidence of postoperative diabetes mellitus (postopdm) was 29%. Postopdm occurred significantly more frequently in patients with malignant pancreatic diseases compared to benign diseases (31.3% vs. 16.7%). The study highlights…
Indirect signs of portal hypertension (pht) don't raise complications risk in hepatocellular carcinoma (HCC) patients undergoing liver resection (LR). However, in patients with hepatic venous pressure gradient (HVPG) ≥10 mmHg, LR significantly increases overall morbidity and liver-related complications risk. Transjugular HVPG assessment is crucial for…
Researchers conducted a nationwide retrospective Dutch cohort study to validate the preoperative and intraoperative Distal Fistula Risk Score (D-FRS) for postoperative pancreatic fistula (POPF) prediction in distal pancreatectomy (DP) patients. The study included 896 patients, of which 152 (17%) developed POPF. The preoperative D-FRS, based…
Despite the positive outcomes reported by high-volume international centers, a multicenter retrospective study in the Netherlands found that surgical resection for locally advanced pancreatic cancer (LAPC) following induction chemotherapy is infrequently performed. Out of 142 patients who underwent resection, only 34.5% met the national comprehensive…
A retrospective cohort study compared robotic and open radical antegrade modular pancreatosplenectomy (ramps) for pancreatic ductal adenocarcinoma (PDAC) and found that robotic ramps had advantages in operative time, estimated blood loss, delayed gastric emptying, and postoperative hospital stay. The rate of severe postoperative complications was…
Researchers conducted a preliminary controlled trial to evaluate the feasibility of using endoscopic ultrasound-guided fiducial markers (EUS-FMP) to guide pancreas surgery. The study enrolled 20 patients with resectable pancreas masses and found that EUS-FMP was successful and technically straightforward before planned surgery. Intraoperative detection of…
The prevalence meta-analysis aimed to determine the rate of low-yield surgery in pancreatic cancer surveillance. A systematic search of relevant studies was conducted, including 5027 patients from 23 articles. The pooled prevalence of low-yield surgery was found to be 2.1%, with a slightly higher prevalence…
A multi-institutional study investigated the accuracy of preoperative imaging in detecting lymph node metastasis (lnm) in patients with pancreatic neuroendocrine tumors (pnets). They found that traditional imaging modalities such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET)-CT, and octreoscan had low…
