Category: HPB & Spleen

GNAS droplet digital PCR enhances mucinous cyst diagnosis

A single GNAS droplet digital PCR (ddPCR) analysis improves the diagnostic accuracy for mucinous pancreatic cystic lesions (MPCNs) using endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Among 140 patients, ddPCR increased MPCN detection to 62% while yielding 100% specificity. The method also identified a third of inconclusive lesions as MPCNs. Importantly, GNAS-ddPCR demonstrated a 24% cost reduction […]

Porto-mesenteric vein resections show promising postoperative outcomes

A study analyzing data from 389 patients undergoing porto-mesenteric vein resections with pancreatectomy found postoperative mortality at 6.4% and major complications at 32.6%. Factors such as a Charlson comorbidity index greater than 4 and preoperative treatments were significant predictors of outcomes. The research generated predictive nomograms demonstrating good potential for forecasting mortality and complications. For […]

Preoperative von Willebrand factor predicts liver failure risk.

Combining preoperative von Willebrand factor antigen (vwf-ag) with existing liver function assessments significantly enhances prediction of posthepatectomy liver failure (PHLF). An analysis of 534 patients from the Mayo Clinic revealed that vwf-ag is an independent predictor of PHLF grade B/C. Utilizing two cutoff values, the positive predictive value improved to 27.9%. This model was validated […]

Modified blumgart anastomosis decreases pancreatic fistula rates

A novel modified blumgart pancreaticojejunostomy technique significantly reduces the incidence of clinically relevant postoperative pancreatic fistula (cr-popf) after pancreaticoduodenectomy. In a study involving patients from January 2020 to December 2024, cr-popf occurred in 6.4% of those undergoing the m-bpj approach compared to 15.6% in the conventional group. This technique, featuring an anchoring method and omental […]

AI Enhances Prognostic Assessments in Resected Pancreatic Cancer

AI-powered spatial analysis of tumor-infiltrating lymphocytes (TILs) in resected pancreatic ductal adenocarcinoma (PDAC) shows promise for prognostic assessment. Among 304 patients, those with an immune-inflamed phenotype demonstrated significantly longer overall and recurrence-free survival compared to other immune profiles. High intratumoral TIL density correlated with extended overall survival (median 52.47 months). The study suggests that AI […]

Wound protectors reduce postoperative complications in pancreatic surgery.

In evaluating 20,960 pancreaticoduodenectomy patients, the use of wound protectors (WPs) significantly decreased serious complications and surgical site infections (SSIs). Among the cohort, 29.4% used WPs, which were linked to an increased operative time but shortened hospital stays. Notably, WP use correlated with a 20% lower rate of serious complications and a 43% reduction in […]

Laparoscopic technique enhances outcomes for necrotizing pancreatitis patients

Laparoscopic retroperitoneal necrosectomy (LRN) significantly improved outcomes for 120 patients with infected necrotizing pancreatitis. Postoperative complications occurred in 34.2%, with a mere 8.3% experiencing surgery-related mortality. Key factors linked to complications included ICU length of stay and extrapancreatic infections. Patients showed marked recovery, with decreased SOFA scores and CT severity indices post-surgery, indicating effectiveness. Notably, […]

Ethylene oxide sterilization proves superior for contaminated endoscopes

A study evaluated the efficacy of two reprocessing methods for endoscopes used in pancreatic encapsulated necrosis with multidrug-resistant infections. The pass rate for endoscopes sterilized with ethylene oxide reached 100%, significantly higher than the 61.54% for those using peracetic acid. Microbiological cultures revealed common multidrug-resistant bacteria, including Pseudomonas aeruginosa. The findings underscore the necessity of […]

Nomogram predicts survival benefit from chemotherapy in liver cancer patients

A nomogram developed from a retrospective study of 11,721 early-stage hepatocellular carcinoma (HCC) patients reveals significant survival benefits from neoadjuvant chemotherapy (NAC) for those classified as high-risk. The model predicts 3-, 5-, and 10-year cancer-specific survival rates based on clinical and demographic factors. Risk stratification effectively identifies patients who may benefit from NAC, supporting personalized […]

Harmonic scalpel’s impact on liver surgery to be assessed

A forthcoming randomized controlled trial aims to evaluate the harmonic scalpel (hs) and cavitron ultrasonic surgical aspirator (cusa) for liver parenchymal transection during laparoscopic liver resections. The study will assess intraoperative blood loss, transection speed, operative time, and postoperative outcomes among patients at West China Hospital. By comparing these two techniques, the trial seeks to […]