This study shows that minimally invasive pancreatoduodenectomy (mipd) and open pancreatoduodenectomy (opd) yield similar outcomes for ampullary adenocarcinoma, regardless of subtype. R1 resection rates were comparable: aac-it (3.4% mipd vs. 6.9% opd) and aac-pb (9.8% mipd vs. 14.9% opd). Five-year overall survival rates were similar: aac-it (56.8% mipd vs. 59.5% opd) and aac-pb (52.5% mipd […]

Study found similar 30-day readmission (23% vs 25%) and mortality rates (3% for both). Median total debridement time was comparable (131 min for LTN vs 134 min for DEN), but complete debridement was achieved more often with DEN (3 times vs 1). LTN reduced length of stay for patients with higher APACHE II scores (8 […]

A new computer vision algorithm shows promise in predicting superior mesenteric artery margin status for pancreatic ductal adenocarcinoma, which could reshape surgical decision-making. The algorithm achieved a sensitivity of 0.43 and an accuracy of 0.85, outperforming expert radiologists and surgeons (0.23 and 0.76, respectively). Specificity was high across all evaluations, with both the algorithm and […]

Surgeons need to know that recent trends show increasing use of imprecise terms for pancreatic head resections, which can impact clinical understanding. Between 2004 and 2023, “pancreaticoduodenectomy” dominated 65.7% of titles, with “pancreatoduodenectomy” at 27.9%. Other variants, including “duodenopancreatectomy,” saw significant decline in use. Inconsistencies affect education and literature indexing, urging a push for standardized […]

Achieving a major pathologic response (mpr) after preoperative treatment for pancreatic ductal adenocarcinoma significantly impacts survival rates. Mpr was noted in just 11.5% of patients, but those who achieved it had a median overall survival of 71.5 months, compared to 40.9 months for non-mpr patients. Recurrence-free survival also improved, with mpr patients experiencing 55.5 months […]

Patients with isolated pulmonary metastases post-resection of pancreatic ductal adenocarcinoma (PDAC) have improved overall survival compared to other metastatic sites. Of 343 patients studied, 21% had lung metastases with a median overall survival of 30 months, compared to 13 months for liver and 20 months for other sites. Recurrences occurred in 85% of patients within […]

Postoperative pancreatic fistula (POPF) significantly hampers chemotherapy delivery in pancreatic cancer patients. 16.8% of patients developed POPF, leading to lower chemotherapy administration rates at 72.1% and a median delay of 56 days. Independent predictors for chemotherapy omission include age ≥ 70 (odds ratio 2.48) and chronic renal failure (odds ratio 4.55) when POPF occurs. In […]

Frailty significantly raises the risk of death and readmission after pancreatic surgery, primarily through postoperative complications. 22.2% of 71,104 patients were frail, with 30-day mortality linked to frailty (aOR 1.29) and readmission (aOR 1.11). Complications mediated 80.72% of the frailty-mortality association, with unplanned reintubation and major infections among the top culprits. Focus on preventing complications […]

Early enteral nutrition (EEN) via nasojejunal tube reduces complications after pancreatoduodenectomy compared to oral nutrition (ON). EEN patients had a mean 90-day complication index of 25.5 vs. 35.8 for ON (p = .02). Overall morbidity was slightly higher in ON (51/59) vs. EEN (45/59), but not statistically significant. Implementing EEN in nutritionally at-risk patients can […]