Endoscopic ultrasound-guided radiofrequency ablation (EUS-RFA) offers a safe, minimally invasive option for patients with branch-duct IPMNs who cannot undergo surgery.

• Technical success reached 100% across 62 procedures, with local control in 98% of lesions.
• Adverse events occurred in 27% of cases, mainly mild abdominal pain; no procedure-related deaths were reported.

This approach maintains pancreas-wide disease control in 80% of patients.

• Smaller cysts and fewer worrisome features correlate with better outcomes.