A miRNA classifier has been developed to detect occult liver metastasis in pancreatic ductal adenocarcinoma (PDAC), revealing significant deregulation of 34 miRNAs in metastatic cases. This classifier, leveraging three key miRNAs (miR-483-5p, miR-6734-5p, and miR-548q), demonstrated high predictive efficacy in identifying metastasis, outperforming CA125 alone while showing comparable results when combined. These findings suggest that […]
Category: HPB & Spleen
Lymph node metastasis worsens survival in colorectal cancer with liver metastasis
Lymph node metastasis (LNM) significantly impacts cancer-specific survival (CSS) in colorectal cancer patients with liver metastasis (CRLM), as demonstrated in an analysis of 11,266 patients. Those with LNM exhibited poorer CSS compared to those without LNM, and this trend remained consistent across different cohorts. Incorporating N staging into the AJCC TNM system, particularly for M1a […]
Diffusion-Weighted MRI Detects More Occult Liver Metastases
In a pilot study involving 38 patients with high-risk pancreatic adenocarcinoma, diffusion-weighted MRI revealed occult liver metastases in 34.2% of cases, significantly higher than peritoneal metastases at 5.3%. With a sensitivity of 86.7% for liver metastases, it allowed avoidance of unnecessary surgical explorations in nearly 40% of patients. Ultimately, intraoperative findings revealed additional metastases in […]
Predictive Model Enhances Surgical Decision-Making for Pancreatic Tumours
A study evaluating tumour pseudocapsule status using CT-based radiomics found that patients with a complete pseudocapsule showed significantly better recurrence-free survival rates than those with an incomplete pseudocapsule. Specifically, 3- and 5-year survival rates were 94.8% and 92.5% for the complete group compared to 76.7% and 70.4% for the incomplete group. This radiomics-predictive model effectively […]
Lactated Ringer’s solution reduces severe pancreatitis risk
A meta-analysis of 1,500 acute pancreatitis patients demonstrated that lactated Ringer’s solution significantly lowers the risk of developing moderate-to-severe pancreatitis compared to normal saline (odds ratio 0.48). Additionally, patients receiving lactated Ringer’s experienced shorter hospital stays, reduced ICU admissions (relative risk 0.42), and fewer local complications (relative risk 0.58). Although there were no significant differences […]
Liver resection offers survival benefits over interventional treatments
A multicenter study with 5,774 hepatocellular carcinoma (HCC) patients with hypohepatia revealed that liver resection (LR) provides significant survival advantages compared to ablation and transarterial chemoembolization (TACE). The findings showed that LR led to lower risks of death and disease progression across various subgroups, making it a superior option for selected intermediate to advanced patients. […]
Updated risk model enhances prediction for pancreatic surgery outcomes
An updated risk prediction model for pancreaticoduodenectomy was developed using data from 35,365 patients in Japan. The study identified 28 factors for surgical mortality and severe complications, and 14 for postoperative pancreatic fistula. The model demonstrated a favorable predictive capability with area under the curve scores of 0.759 for mortality and 0.712 for complications in […]
Gradient boosting model predicts liver metastasis in pancreatic neuroendocrine tumors.
A study utilizing data from 7,463 pancreatic neuroendocrine tumor (PanET) patients developed a gradient boosting machine (GBM) model, marking it as the most effective tool for predicting liver metastasis. The model achieved an AUC of 0.937 and an accuracy of 0.87, highlighting independent risk factors like T-stage, N-stage, and previous treatments. It culminated in a […]
Certification improves surgical outcomes in pancreaticoduodenectomy
An analysis of nearly 79,000 pancreaticoduodenectomy reports from 2014 to 2020 revealed a significant reduction in adjusted odds ratios for surgical mortality—from 0.906 to 0.647. Participation in a nationwide clinical database and surgeon certification system correlated with improved outcomes, including a notable decrease in grade C pancreatic fistula incidence. Board-certified surgeons consistently outperformed their non-certified […]
Robotic pancreaticoduodenectomy lowers complications and hospital stays
A recent study revealed that robotic pancreaticoduodenectomy (RPD) significantly reduces the rate of clinically relevant pancreatic fistulas (10%) compared to open pancreaticoduodenectomy (OPD) (33.3%). Patients undergoing RPD also experienced shorter hospital stays (15 days) versus 22.5 days for OPD. Despite longer operative times for RPD, overall hospital costs were similar between the two approaches, as […]