Ultrasonography proved vital in assessing postoperative fluid collections after pancreaticoduodenectomy. A study of 309 patients revealed that those undergoing laparoscopic pancreaticoduodenectomy (LPD) experienced significantly fewer fluid collections (39.2% vs. 59.3%) and shorter hospital stays (16 vs. 21 days). Additionally, LPD patients had reduced fever duration, faster catheterization, fewer required tubes, and shorter extubation times. These […]

Through a comprehensive review, researchers highlight the efficacy of proton beam therapy (PBT) in managing hepatocellular carcinoma (HCC), particularly for patients with portal vein tumor thrombosis (PVTT). PBT demonstrates promising tumor local control and overall survival rates while offering a safer alternative to traditional photon radiotherapy. It effectively downstages HCC for liver transplantation, proving non-inferior […]

Indocyanine green (ICG) significantly boosts procedural adjustments and tumor identification in minimally invasive liver surgery, according to findings involving 72 patients. Intraoperative ICG visualization proved “helpful” for 88% of surgeons, with meaningful differences in tumor positivity (12.2% in the ICG group vs. none in the control). This led to higher rates of frozen section analysis […]

Improved outcomes for patients with initially unresectable hepatocellular carcinoma are linked to the depth of radiographic response after systemic therapy prior to hepatectomy. In a study of 81 patients, radiographic response emerged as an independent prognostic factor for both recurrence-free and overall survival. Notably, achieving a radiographic response greater than 40% or 50% significantly correlated […]

Neoadjuvant therapy (NAT) with FOLFIRINOX significantly enhances resectability and overall survival (OS) in patients with locally advanced pancreatic cancer (LAPC). This umbrella review of nine systematic reviews highlights that FOLFIRINOX leads to higher R0 resection rates compared to gemcitabine/nab-paclitaxel, with improved OS. Furthermore, surgical resection post-NAT provides better survival outcomes than induction therapy alone. Cost-effectiveness […]

A novel nomogram has been developed to accurately predict late extraluminal postpancreatectomy hemorrhage (lepph) in patients with postoperative pancreatic fistula following pancreaticoduodenectomy. Utilizing a combination of key independent risk factors such as dorsal fluid accumulation and positive cultures in drainage fluid, the model demonstrated high predictive accuracy with c-index values of 0.932, 0.924, and 0.954 […]

A novel preoperative risk score predicts 90-day mortality after major liver resection, identifying five key risk factors: age ≥ 65 years, type 2 diabetes, a diagnosis of primary liver cancer, ASA ≥3, and extended hemihepatectomy. In a cohort of 513 patients, the 90-day mortality rate was 10.8%, with predicted rates of 3.5% for low risk, […]

A novel preoperative model for predicting microvascular invasion (MVI) in hepatocellular carcinoma (HCC) has been developed based on key clinical characteristics and serum biomarkers. Analyzing 1,027 patient cases, independent risk factors identified include hepatitis B virus infection, tumor size, and several alpha-fetoprotein markers. The model demonstrated strong diagnostic performance, with AUC values of 0.806 and […]

A novel surface microdialysis probe demonstrated safety and feasibility for monitoring liver metabolism after resection in 17 patients. Complications were minimal and consistent with Clavien-Dindo classification. Key metabolites, including glucose, lactate, and pyruvate, were analyzed, revealing significantly higher lactate in liver samples compared to plasma, particularly in ischemic areas. Notably, the lactate/pyruvate ratio correlated with […]