A machine learning model developed from 376 intrahepatic cholangiocarcinoma patients effectively predicts textbook outcomes. Key preoperative factors include Child-Pugh classification, ECOG score, hepatitis B status, and tumor size. The model achieved high accuracy during internal (AUC = 0.8825) and external validation (AUC = 0.8346). Survival analysis indicated that patients achieving textbook outcomes had disease-free survival […]
Category: HPB & Spleen
Heterogeneity in outcome reporting impacts pancreatic surgery research
A systematic review of 156 studies on curative surgery for pancreatic adenocarcinoma reveals significant inconsistencies in outcome reporting. Researchers identified 2088 reported outcomes, resulting in 399 unique endpoints, with no single outcome universally reported. Alarmingly, 45% of these outcomes were undefined, indicating a lack of clarity. Most outcomes focused on adverse events and care delivery, […]
Soluble TREM2 predicts liver dysfunction after surgery.
Soluble TREM2 (strem2) levels in plasma effectively reflect liver fibrosis status and predict postoperative liver dysfunction in patients undergoing liver resection. In a cohort of 108 patients assessed before surgery and on postoperative days one and five, strem2 demonstrated sensitivity for early, asymptomatic chronic liver disease. Notably, even patients without end-stage liver disease showed distinct […]
Comprehensive Classification of Right Intrahepatic Portal Vein Branching
A study analyzing the branching patterns of the right intrahepatic portal vein identified 12 distinct types, emphasizing the anatomical variations of the right anterior and posterior portal veins. Three-dimensional visualization technology was utilized to analyze 711 patients, revealing the cranio-caudal and ventro-dorsal configurations among others. These findings provide clinicians with critical insights into portal vein […]
Adjuvant PD-1 inhibitors enhance survival in high-risk HCC patients.
In a study involving 199 hepatocellular carcinoma patients, the use of adjuvant PD-1 inhibitors significantly improved both recurrence-free survival (RFS) and overall survival (OS) rates. After propensity score matching, 1-year RFS was 87.1% for those receiving PD-1 inhibitors versus 44.6% for non-recipients, while 1-year OS rates were 98.5% versus 90.7%, respectively. The findings suggest that […]
Metabolic syndrome increases cholangiocarcinoma risk significantly.
A large-scale population-based cohort study involving 4,932,211 adults revealed that individuals with metabolic syndrome face a significantly heightened risk of cholangiocarcinoma, with a multivariate-adjusted hazard ratio of 1.20. During 35,879,371 person-years of follow-up, there were 6,117 identified cases, with incidence rates rising in correlation with the number of metabolic components. Those with five metabolic factors […]
Broad-spectrum penicillin antibiotics improve pancreatoduodenectomy outcomes
A systematic review involving 12,469 patients indicates that broad-spectrum penicillin-based antibiotics (bs-ab) notably reduce surgical site infections, postoperative pancreatic fistula rates, and mortality compared to standard cephalosporins. Specifically, bs-ab led to a 47% decrease in surgical site infections and a 38% reduction in postoperative pancreatic fistulas. Notably, benefits were enhanced for patients with preoperative biliary […]
Combined imaging improves accuracy for detecting liver metastases
Combining contrast-enhanced CT with MRI significantly boosts the detection of colorectal liver metastases, achieving sensitivity rates of 96.5% compared to 90.6% for MRI alone. Specificity also improved, from 95.3% to 98.3%. Notably, radiologists reported higher diagnostic confidence in 78.8% of cases with the combined approach, up from 64.7% with MRI alone. Additionally, inter-observer agreement reached […]
Prognostic model predicts recurrence and treatment response in HCC
A novel prognostic model utilizing pathological signatures effectively predicts postoperative recurrence risk and sorafenib response in hepatocellular carcinoma (HCC) patients. Analyzed across 287 non-treated patients, the model achieved AUROC values of 0.818 and 0.811 for predicting one and two-year recurrence respectively. Validation with an external cohort confirmed its predictive power. Additionally, it successfully stratified sorafenib-treated […]
Transarterial embolization effectively manages liver cancer hemorrhages
Transarterial embolization (TAE) demonstrates a 100% hemostasis success rate in treating ruptured hemorrhages and postablation bleeding in liver cancer patients. The 30-day survival rates were 90.91% for the rupture group and 100% for the ablation group, with 1-year survival rates of 45.45% and 85.19%, respectively. Although liver function changes occurred postoperatively, they remained comparable to […]