A case study demonstrated the effectiveness of a multidisciplinary approach in managing perihilar cholangiocarcinoma, involving neoadjuvant therapy and interventional radiology. Neoadjuvant chemotherapy significantly reduced the tumor size, facilitating an r0 surgical resection. Additionally, interventional radiology played a critical role in addressing postoperative complications, including a life-threatening pulmonary embolism, through techniques like percutaneous pharmaco-mechanical thrombectomy. This […]

Hepatectomy guided by indocyanine green fluorescence navigation has demonstrated significant benefits over conventional methods for treating hepatocellular carcinoma. Key findings reveal reduced operation time, intraoperative blood loss, and lower transfusion rates, while improving the R0 resection rate and decreasing postoperative complications. Notably, the length of hospital stay showed no significant differences. These results suggest that […]

In biliary tract cancers (BTCs), genomic analysis revealed distinct variations in mutations across cancer subtypes based on anatomic and geographic factors. Notably, intrahepatic cholangiocarcinoma samples showed prevalent alterations in IDH1 and FGFR2, while gallbladder cancers frequently displayed TP53, ERBB2, and SMAD4 mutations. Co-mutations were ubiquitous, with significant correlations between certain co-alterations and poorer overall survival. […]

In a phase 3 study involving 616 patients with unresectable hepatocellular carcinoma, the combination of durvalumab and bevacizumab, alongside transarterial chemoembolisation (TACE), significantly improved median progression-free survival to 15 months compared to 8.2 months with placebo. The hazard ratio for progression-free survival was 0.77, indicating a notable benefit, while safety assessments revealed manageable adverse events. […]

A nomogram was developed to predict early cancer-related death (ecrd) due to recurrence in hepatocellular carcinoma (HCC) patients with BCLC stage B/C. Analysis of 672 patients revealed that the alpha-fetoprotein-tumor burden score, BCLC stage, and AST to ALT ratio were significantly associated with ecrd. The model demonstrated strong predictive efficacy in both training (AUC: 0.754) […]

A new laparoscopic liver resection technique utilizing the ventral avascular area of the inferior vena cava shows promise in improving surgical outcomes. In a study of 256 patients, this method yielded significantly larger tumor resections and reduced intraoperative complications, such as bleeding and tumor compression, compared to traditional approaches. The technique allows for a safer […]

Following neoadjuvant treatment with FOLFIRINOX for pancreatic adenocarcinoma, researchers observed a median overall survival of 177 months for patients achieving complete pathological response (cpr). Among 101 patients studied, overall survival rates after 1, 3, 5, and 10 years were 93%, 75%, 63%, and 51%, respectively. However, one-third experienced disease recurrence, with preoperative chemoradiotherapy correlated to […]

Comprehensive management strategies for hilar cholangiocarcinoma (h-cca) highlight the urgent need for effective treatment options. With the disease often presenting in advanced stages, radical resection remains crucial for prolonging survival. Recent advancements in imaging techniques and the role of immunotherapy offer new avenues for therapy. Additionally, innovations such as novel fiberscopes utilizing near-infrared light enable […]

The development of predictive models for postoperative complications and prognosis significantly aids patients with hepatocellular carcinoma combined with clinically significant portal hypertension (CSHP). Researchers identified key risk factors—including ALBI grade and portal vein occlusion time—and created nomograms demonstrating good predictive performance. These models achieved c-index values of 0.723 for complications, 0.635 for recurrence, and 0.734 […]