A systematic review and network meta-analysis of eight randomized controlled trials involving 1,803 biliary tract cancer patients found that adjuvant chemotherapy significantly enhances relapse-free survival and overall survival compared to observation alone. Notably, gemcitabine-based chemotherapy outperformed fluorouracil-based treatments in reducing recurrence rates. The analysis indicates that postoperative chemotherapy should be a standard recommendation following curative […]

A study involving 755 laparoscopic hepatectomy patients found that maintaining a lowest central venous pressure (CVP) below 2 mmHg significantly increases the incidence of posthepatectomy liver failure (PHLF). After propensity score matching, results indicated that low CVP levels correlated with higher PHLF occurrence and elevated intraoperative lactate levels, particularly among elderly patients or those with […]

Clinicians face numerous challenges incorporating advances in hepatocellular carcinoma (HCC) treatment into practice. Revised EASL guidelines highlight personalized surveillance based on risk assessment, standardized imaging procedures, and minimally invasive surgery for complex cases. They emphasize the critical role of liver transplantation, therapeutic transitions, and the integration of immunotherapy at different disease stages. A multidisciplinary team […]

Clinical outcomes from a study of 113 pancreatic cancer patients indicate that preserving the portal/superior mesenteric vein during pancreaticoduodenectomy results in similar oncologic outcomes to resection, with better vessel-functional outcomes. While there was no significant difference in R0 resection rates, overall survival, or recurrence-free survival, the preservation group experienced significantly lower rates of vein stenosis […]

A predictive and prognostic signature, named chemoresist, effectively identifies pancreatic ductal adenocarcinoma patients likely to benefit from adjuvant chemotherapy. In a multicenter study involving 551 patients, the chemoresist classifier demonstrated significant survival differences between high- and low-score patients, outperforming traditional TNM staging. It achieved higher predictive accuracy for two-year overall survival (AUC 0.788 vs. 0.636, […]

A meta-analysis of 10 studies involving 3,505 patients found that the no-drainage approach following left pancreatectomy is associated with a significantly lower incidence of postoperative pancreatic fistula (grade B/C) and a reduced length of hospital stay compared to the traditional drainage method. Major morbidity rates showed no substantial difference. These results suggest that avoiding prophylactic […]

A comprehensive consensus on robotic hepatectomy has been established by European experts, detailing techniques for different hepatectomy types. This expert report emphasizes best practices, from patient selection to postoperative care, aiming to standardize training and enhance surgical outcomes in robotic liver surgery. Addressing the current lack of consistent training materials, the findings encourage the safe […]