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A meta-analysis of 1500 patients found that lactated Ringer's (LR) solution significantly reduces the risk of progressing to moderate-to-severe acute pancreatitis compared to normal saline (NS), with an odds ratio of 0.48. Patients receiving LR also experienced shorter hospital stays and lower ICU admission rates.…
A deep learning-based clinical-radiomics model has shown strong predictive capability for durable clinical benefit (dcb) in patients with potentially convertible hepatocellular carcinoma receiving immune checkpoint inhibitors (ICIs). The model achieved an area under the curve (AUC) of 0.96 in training and 0.88 in testing, accurately…
Recent advancements in fluorescence-guided surgery provide significant improvements in identifying hepatocellular carcinoma (HCC) lesions. Indocyanine green has been essential for delineating tumor boundaries yet lacks the ability to differentiate between benign and malignant tumors. This review discusses clinical applications and emerging alternatives, such as aggregation-induced…
In a cohort study of 785 patients with pancreatic ductal adenocarcinoma, the presence of mutant KRAS circulating tumor DNA (ctDNA) was linked to higher metastatic risk and poorer survival outcomes. Out of those tested, 104 showed plasma MKRAS positivity, correlating with increased likelihood of metastatic…
A multi-center study of 303 patients with colorectal liver metastases revealed no significant difference in early recurrence patterns after resection versus thermal ablation. Both treatments showed similar 6-month recurrence-free survival rates; however, thermal ablation demonstrated a lower incidence of serious complications and shorter hospitalization. Key…
A study analyzing 192 robotic gastro-enterostomy procedures found that enhanced surgical performance, assessed via objective structured assessment of technical skills (OSATS), correlates with a reduced incidence of delayed gastric emptying (DGE). DGE occurred in 21.9% of patients, with an OSATS score above 25 associated with…
A novel machine learning model successfully predicts postpancreatectomy acute pancreatitis (PPAP) in patients following pancreaticoduodenectomy. In a cohort of 381 patients, 88 (23.09%) developed PPAP, which was notably associated with a higher occurrence of postoperative pancreatic fistulas (55.68%). Various algorithms, including logistic regression and gradient…
A novel predictive and prognostic signature, named chemoresist, was developed to assess the outcomes of patients with pancreatic ductal adenocarcinoma (PDAC) post-surgery and adjuvant chemotherapy. In a multicohort analysis, significant survival differences were noted between high and low chemoresist patients, with median overall survival reaching…
A systematic review and meta-analysis involving 15,817 patients revealed that avoiding routine abdominal drainage following left pancreatectomy significantly reduces major morbidity, postoperative pancreatic fistula rates, readmissions, and surgical site infections. The no-drain group experienced a 23% reduction in major complications and substantially lower rates of…
A multicenter study involving 2828 patients with hepatocellular carcinoma (HCC) and microvascular invasion revealed that early recurrence (ER) occurs more frequently within the first year after hepatectomy, leading to poorer outcomes than late recurrence (LR). Median overall survival was 20.2 months for ER compared to…
