Transabdominal ultrasonography (TAUS) shows high compatibility with endoscopic retrograde cholangiopancreatography (ERCP) in diagnosing bile duct obstructive lesions. A retrospective study analyzed patient data and found substantial agreement in identifying conditions such as cholangiocarcinoma, bile duct stricture, and pancreatic cancer, with compatibility rates between 71.4% and 100%. TAUS offers a reliable, non-invasive, and radiation-free imaging option […]
Category: HPB & Spleen
Metabolic Changes and GLP-1 Levels Predict Liver Failure
Significant metabolic alterations and the dynamics of GLP-1 and GLP-2 were identified during liver resection in patients, particularly linking these changes to posthepatectomy liver failure (PHLF). Of the patients studied, metabolic clustering showed that 93% of PHLF individuals fell within one cluster. Preoperative GLP-1 levels were notably elevated in PHLF patients, and its incorporation into […]
Nanovesicles enhance chemosensitivity in cholangiocarcinoma models
Aptamer-decorated milk-derived nanovesicles (mnvs) effectively targeted cholangiocarcinoma (cca) cells, promoting the delivery of short interfering RNAs (siRNAs) that inhibited key gene expressions. This selective uptake led to reduced tumor growth and increased reactive oxygen species production. Notably, the combined treatment with nanovesicles and chemotherapy showed enhanced therapeutic efficacy in both immunocompetent and patient-derived xenograft models. […]
Prognostic factors vary between neoadjuvant and chemo-naïve patients.
Neoadjuvant therapy changes the prognostic landscape for patients with resected pancreatic ductal adenocarcinoma (PDAC). In a study of 2,760 patients, independent predictors of overall survival (OS) differed significantly: chemotherapy-naïve patients were affected by age, CA19-9 levels, and tumor stage, while neoadjuvant therapy patients faced challenges like CA19-9 normalization and nodal presence. These insights led to […]
ALBI-GGT Score Improves Prognostic Accuracy for HCC Patients
A novel ALBI-GGT score was developed to enhance prognostic accuracy for patients undergoing hepatocellular carcinoma (HCC) resection. This composite score combines the albumin-bilirubin and gamma-glutamyl transferase metrics, showing superior predictive ability for long-term survival compared to either measure alone. In multivariable analysis, both components significantly predicted overall mortality, with the ALBI-GGT score achieving the highest […]
Antiviral therapy significantly lowers late recurrence in HBV-related HCC
A retrospective cohort study revealed that antiviral therapy (AVT) markedly reduces late recurrence rates in patients with hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) and compensated cirrhosis post-hepatectomy. The 1-, 3-, 5-, and 10-year recurrence rates for the AVT group were significantly lower than those of the non-AVT group (26%, 49%, 65%, and 76% vs. […]
Key risk factors identified for predicting complications after pancreatoduodenectomy
A comprehensive review found that the main pancreatic duct diameter and pancreatic texture are critical for predicting postoperative pancreatic fistula, while age and ASA score are significant for other complications. Of 90 studies evaluated, only 26% of risk stratification tools had external validation, with even fewer (20%) for artificial intelligence models. The findings emphasize the […]
ASAP Score Predicts Recurrence in Hepatocellular Carcinoma Patients
The ASAP score, evaluated in a cohort of 1,239 patients undergoing hepatic resection for hepatocellular carcinoma (HCC), revealed significant prognostic value. A cutoff of 4.8 classified patients into high and low-risk groups, showing that those with higher scores faced significantly greater 5-year recurrence rates (73.9% vs. 51.0%). The study establishes the ASAP score’s role in […]
Research highlights global trends in necrotizing pancreatitis studies
The analysis of 929 articles on necrotizing pancreatitis revealed China as the leading contributor, followed by the United States and India. Notable findings included a focus on minimally invasive treatments, with key publications in specialized journals like “Pancreatology.” Despite increased research efforts over the past decade, the mortality rate for pancreatic necrosis remains concerning, indicating […]
Explainable machine learning model predicts mortality in infected pancreatic necrosis
An explainable machine learning model for predicting 90-day mortality in patients with infected pancreatic necrosis (IPN) has shown promising results. The final model, developed from a cohort of 344 patients, achieved a c-index of 0.863 in internal validation and 0.857 in external validation, outperforming nine other models. Key mortality predictors included multiple organ failure and […]