Iatrogenic colon perforation, a rare but serious complication of colonoscopy, was studied to determine effective treatment approaches. Out of 51 cases, 84% required surgery. Notably, laparoscopic surgery was performed in 88% of cases, demonstrating its safety and feasibility. Laparoscopic primary suturing was successful in 80% of cases, with a high recovery rate of 96%. The […]
Category: Intestine and Lower Gastrointestinal Tract
Timely Closure of Ileostomies: A Regional Australian Hospital’s Experience
This study explores the timing and reasons for delaying loop ileostomy closure in regional Australian hospitals. Of the 123 patients who received loop ileostomies between 2010 and 2020, 86.2% had their stomas reversed. Patients with rectal cancer experienced a median time to closure of 8.5 months, while non-rectal cancer patients had a median closure time […]
Repeat Cytoreduction and HIPEC Boost Survival in Recurrent Appendiceal Adenocarcinoma
When dealing with recurring mucinous appendiceal adenocarcinoma, undergoing repeat cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) can be a game-changer. This study from MD Anderson Cancer Center reveals that patients who opt for repeat CRS/HIPEC enjoy similar recurrence-free survival compared to those initially treated, and even better overall survival than patients relying solely on […]
Women Fare Better in Surgical Outcomes for Inflammatory Bowel Disease
In this study, researchers delved into surgical outcomes for inflammatory bowel disease patients based on their sex. Analyzing data from over 3,000 patients, they discovered that women had lower odds of serious adverse events compared to men. This difference was particularly notable in patients with ulcerative colitis, where women had a 54% lower risk of […]
Colorectal Mixed Neuroendocrine-Non-Neuroendocrine Neoplasms Benefit from Adjuvant Chemotherapy
This study delved into the rare world of mixed neuroendocrine-non-neuroendocrine neoplasms in colorectal cancer and their more aggressive counterpart, neuroendocrine carcinomas. They found that adjuvant chemotherapy significantly improved survival for patients with stage III mixed neuroendocrine-non-neuroendocrine neoplasms and neuroendocrine carcinomas. The median survival for these groups was similar, emphasizing the importance of adjuvant treatment in […]
Transanal Surgery Shows Advantages Over Laparoscopy in Rectal Cancer
This meta-analysis evaluated the outcomes of transanal total mesorectal excision (TaTME) versus laparoscopic TME (LaTME) for rectal cancer. Analyzing data from 22 studies comprising 5056 patients, including randomized controlled trials and prospective studies, revealed that TaTME had a lower conversion rate and better circumferential resection margin (CRM) outcomes than LaTME. There were no significant differences […]
Persistent NIR Fluorescent Tattoos Improve Tumor Localization in Minimally Invasive Colorectal Surgery
This innovative study tackles the challenge of precisely locating tumors during minimally invasive colorectal surgery. Traditionally, blue dye has been used for preoperative marking, but it can lead to complications when spilled inside the body. The researchers introduced a new method using a near-infrared (NIR) fluorescent marker called AFS81x. In experiments on pigs, they successfully […]
KRAS Mutation in Colon Cancer Linked to Poorer 2-Year Survival
In a study on non-metastatic colon cancer patients, researchers explored conditional overall survival (COS) considering laterality, microsatellite instability (MSI), and KRAS mutation status. Among 4,838 patients, those with mutated KRAS experienced worse COS, implying a more aggressive disease course, with a higher risk of death 2 years post-diagnosis. While laterality and MSI status didn’t significantly […]
Machine Learning Model Predicts Benign Anastomotic Strictures in Rectal Cancer Patients
Aiming to improve the prediction of benign anastomotic strictures (BAS) in patients who’ve undergone rectal cancer surgery, a study harnessed machine learning. Data from 1,973 patients were analyzed using multiple machine learning models, with the random forest (RF) model emerging as the best predictor of BAS. The RF model achieved an impressive area under the […]
Comparing Laparoscopic and Trans-Anal TME for Rectal Cancer: Insights from RCT Meta-Analysis
In a meta-analysis of randomized controlled trials, researchers evaluated two surgical approaches for rectal cancer: laparoscopic total mesorectal excision (LaTME) and trans-anal TME (TaTME). Analyzing data from 1,691 patients across six trials, they found no significant differences in morbidity, mortality, conversion to open surgery, or anastomotic leakage between the two techniques. However, TaTME patients were […]