BMC Surg2 Apr 2024
Researchers demonstrated the feasibility of using risk-adjusted cumulative sum to monitor outcomes after colorectal operations and identify performance variations. This method accurately tracked surgeon-specific outcomes, adjusting for patient-level risk factors. Outliers in performance were promptly identified at the surgeon, divisional, and institutional levels, contributing to…
BMC Surg2 Apr 2024
Patients with KRAS-mutated colorectal liver metastases had shorter overall and disease-free survival after liver resection. In these cases, the resection margin did not affect oncologic outcomes. However, for KRAS wild-type tumors, achieving an R0 resection was crucial for prolonged overall and disease-free survival. Primary tumor…
Inflamm Bowel Dis2 Apr 2024
Endoscopic cuffitis occurred in approximately 60% of patients who underwent restorative proctocolectomy with stapled ileal pouch–anal anastomosis, and was significantly associated with extensive disease and exposure to multiple biologics before colectomy. Older age, extensive disease, exposure to biologics before colectomy, and exposure to at least…
Dis Colon Rectum1 Apr 2024
Pelvimetry measurements using CT scans can predict the quality of total mesorectal excision in rectal cancer surgery. Factors like a deeper sacral curve and greater transverse distance of pelvic outlet were associated with incomplete excision. An increased area of pelvic inlet was linked to a…
HPB & Spleen31 Mar 2024
Neoadjuvant chemotherapy for initially resectable colorectal cancer liver metastasis aims at tumor downsizing, evaluating biological behavior, and reducing postoperative recurrence risk. Balancing tumor reduction benefits with hepatic injury risks and the need for timely surgery is crucial. Precision medicine's role in tailoring neoadjuvant regimens, such…
Gastrointest Endosc30 Mar 2024
Colonic-enteric lumen-apposing metal stents (LAMS) showed high technical success (100%) and clinical success (92.3%) in managing small-bowel obstruction (SBO) in patients who are not surgical candidates due to malignancy. Adverse events occurred in 15.4% of patients, including bleeding, diarrhea, and postprocedure sepsis. Patients were able…
Intestine and Lower Gastrointestinal Tract30 Mar 2024
Stenting as a bridge to surgery for non-metastatic obstructing left-sided colorectal cancer increases the risk of peritoneal recurrence, especially in cases of T4 tumors, diabetes, and nodal positivity. However, no significant differences were found in overall survival, cancer-specific survival, or recurrence-free survival between stenting and…
JAMA Surg29 Mar 2024
Moabp significantly reduced overall postoperative complications, surgical site infections (SSIs), and anastomotic dehiscences in patients undergoing elective rectal resection compared to those receiving mechanical bowel preparation (MBP) plus a placebo. Patients in the Moabp group had lower rates of complications and SSIs, highlighting the potential…
Ann Surg Oncol29 Mar 2024
Systematic review and meta-analysis of hepatic artery-based therapies and systemic chemotherapy for unresectable colorectal liver metastases showed high overall survival rates for hepatic artery infusion and favorable outcomes compared to doublet chemotherapy in specific subgroups. Triplet chemotherapy had the best outcomes but with higher toxicity…
Dis Colon Rectum28 Mar 2024
First-degree relatives of patients with early-onset colorectal cancer have low rates of colorectal cancer screening, with only 44% undergoing screening despite guidelines recommending screening starting at age 40 or 10 years before the age of their relative's diagnosis. Factors such as race, stage of disease,…
